中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (7): 502-505.doi: 10.3760/cma.j.issn.0412-4030.2019.07.014
陈怡雯 苏婷 苏忠兰
收稿日期:
2018-12-25
修回日期:
2019-02-20
出版日期:
2019-07-15
发布日期:
2019-07-01
通讯作者:
苏忠兰
E-mail:alice_su2595@126.com
基金资助:
Chen Yiwen, Su Ting, Su Zhonglan
Received:
2018-12-25
Revised:
2019-02-20
Online:
2019-07-15
Published:
2019-07-01
Contact:
Su Zhonglan
E-mail:alice_su2595@126.com
Supported by:
摘要: 【摘要】 银屑病是一种慢性炎症性皮肤病,其发病机制尚不明确,目前认为由遗传、环境、免疫等共同介导。信号转导与转录激活因子3(STAT3)是一种重要的转录因子,与肿瘤、自身免疫性疾病等相关,通过参与Th17细胞分化、角质形成细胞过度增生与异常分化、与炎症细胞相互作用、真皮血管增生等重要病理过程在银屑病发病中起关键作用。近年来,针对STAT3及其上游JAK激酶治疗银屑病的研究显示出较好的有效性和安全性。本文就银屑病与STAT3的关系进行综述,为以STAT3为靶点治疗银屑病的可行性提供依据。
陈怡雯 苏婷 苏忠兰. 银屑病与STAT3[J]. 中华皮肤科杂志, 2019, 52(7): 502-505.
Chen Yiwen, Su Ting, Su Zhonglan. Association between psoriasis and STAT3[J]. Chinese Journal of Dermatology, 2019, 52(7): 502-505.
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