中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (2): 84-86.

• 论著 • 上一篇    下一篇

寻常型银屑病患者皮损TNF受体和ICAM-1及淋巴细胞功能相关抗原的表达

张士发1, 林俊萍2, 王雅坤2, 梁再赋2, 陈洪铎2, 顾绍裘2   

  1. 1. 沈阳军区总医院皮肤科, 沈阳 110015;
    2. 中国医科大学第一临床学院皮肤科
  • 收稿日期:1997-06-07 修回日期:1997-10-24 出版日期:1998-04-15 发布日期:1998-04-15

Expressions of TNF Receptors, ICAM-1 and LFA-1 in Lesional Skin of Psoriasis Vulgaris

Zhang Shifa1, Lin Junping2, Wang Yakun2   

  1. Department of Dermatology, General Hospital of Shenyang Military Region, Shenyang 110015
  • Received:1997-06-07 Revised:1997-10-24 Online:1998-04-15 Published:1998-04-15

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摘要： 目的 探讨肿瘤坏死因子(TNF)α在寻常型银屑病的作用机理。方法 采用免疫组织化学方法对寻常型银屑病皮损55000(p55)和75000(p75)TNF受体、细胞间粘附分子(ICAM)-1、白细胞功能相关抗原(LFA)-1的表达进行了检测。结果 正常人皮肤不表达p55、p75、ICAM-1和LFA-1,基底细胞散在表达p55和p75。寻常型银屑病皮损表皮表达p55、p75和ICAM-1;真皮内浸润单一核细胞表达p55、p75和LFA-1;表皮角朊细胞(EKC)p55表达强度与其ICAM-1表达强度呈显著正相关(r's=0.704,P<0.05),而p75则与ICAM-1不相关(r's=0.589,P>0.05);表皮角朊细胞ICAM-1表达强度与真皮内浸润单一核细胞数量呈显著正相关(r's=0.724,P<0.05)。结论 TNFα可通过p55介导而诱导表皮角朊细胞表达ICAM-1,后者则诱导真皮内单一核细胞浸润,从而促进银屑病的发生和发展。

关键词: 银屑病, 受体, 肿瘤坏死因子, 胞间粘附分子, 抗原, 淋巴细胞功能相关

Abstract: Objective To study the mechanism of tumor necrosis factor(TNF) α in psoriasis vulgaris. Methods The expressions of 55-kD(p55) and 75-kD(p75) TNF receptors, intercellular adhesion molecule(ICAM)-1, lymphocyte function associated antigen(LFA)-1 in the lesional skin of psoriasis vulgaris were detected by immunohistochemical method. Results Normal skin did not express p55, p75, ICAM-1 and LFA-1, the epidermis of the lesional skin expressed p55, p75 and ICAM-1, the infiltrating mononuclear cells (MNCs) in the dermis expressed p55, p75 and LFA-1 in psoriasis vulgaris. The intensities of staining of the p55 and ICAM-1 on epidermal keratinocytes(EKC) were significantly correlated (r's=0.704, P<0.05), but p75 and ICAM-1 were not correlated (r's=0.589, P>0.05). The staining intensity of ICAM-1 on EKC and the number of infiltrating MNCs in the dermis was significantly correlated (r's=0.724, P<0.05) in psoriasis vulgaris. Conclusion TNFα may induce the expression of ICAM-1 on KC through the mediation of p55 and ICAM-1 induces the infiltration of MNCs in the dermis, which promotes the development and progression of psoriasis vulgaris.

Key words: Psoriasis, Receptors,tumor necrosis factor, Intercellular adhesion molecule-1, Antigen,lymphocyte function associated；