特应性皮炎样移植物抗宿主病的临床特点与诊疗策略

摘要/Abstract

摘要： 移植物抗宿主病（graft-versus-host disease, GVHD）常见于异基因造血干细胞移植术后的一种累及多器官的免疫性疾病［１］。少数实质器官移植也可能产生GVHD，如肝移植等。皮肤是GVHD最易受累且最易发现的器官，对全身其他器官的排异反应有重要的预警作用［2］。随着移植术的广泛开展，累及皮肤的移植物抗宿主病不断增多并呈多样化，常见的皮肤表现如扁平苔藓样，硬皮病样和皮肤异色症样GVHD［3-5］。近年来陆续报道了一些罕见皮肤表现的GVHD，包括红斑狼疮样［6］，皮肌炎样［7］，银屑病样［8］，鱼鳞病样［9］，大疱性类天疱疮样［１0］，以及多形红斑样［1１］等表现的移植物抗宿主病。1999年，Tanasescu等［１2］报道了1例湿疹样GVHD。2007年Creamer等［１3］将10例湿疹样GVHD的临床特征及其对UVA治疗的疗效观察进行了研究报道。我国报道了一种特应性皮炎样移植物抗宿主病（atopic dermatitis-like GVHD）［１4-15］，并且发现具有这种皮肤表现的GVHD逐渐增多，现将特应性皮炎（AD）样移植物抗宿主病概述如下……

关键词: 移植物抗宿主病, 皮炎，特应性, 临床研究, 治疗, 诊断

Key words: Clinical Study, treatment

魏瑾张建中. 特应性皮炎样移植物抗宿主病的临床特点与诊疗策略[J]. 中华皮肤科杂志, 2014, 47(9): 685-686.

Jin WEI. Atopic dermatitis?鄄like graft?鄄versus?鄄host disease: clinical features, diagnosis and treatment[J]. Chinese Journal of Dermatology, 2014, 47(9): 685-686.

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