氨基酮戊酸光动力疗法治疗皮肤鳞状细胞癌的现状、挑战和思考

doi:10.35541/cjd.20260178

中华皮肤科杂志 ›› 2026, Vol. 59 ›› Issue (7): 626-631.doi: 10.35541/cjd.20260178

• 专家论坛·光皮肤病学 • 上一篇下一篇

氨基酮戊酸光动力疗法治疗皮肤鳞状细胞癌的现状、挑战和思考

张国龙赵子君

同济大学附属皮肤病医院光医学研究所，上海 200443

收稿日期:2026-04-01 修回日期:2026-06-16 发布日期:2026-07-03
通讯作者: 张国龙 E-mail:glzhangtj@tongji.edu.cn
基金资助:
国家自然科学基金（82272761）

Aminolevulinic acid-based photodynamic therapy for cutaneous squamous cell carcinoma: current status, challenges, and perspectives

Zhang Guolong, Zhao Zijun

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China

Received:2026-04-01 Revised:2026-06-16 Published:2026-07-03
Contact: Guo-Long Zhang E-mail:glzhangtj@tongji.edu.cn
Supported by:
National Natural Science Foundation of China（82272761）

摘要/Abstract

摘要： 【摘要】皮肤鳞状细胞癌（cSCC）好发于头面部曝光部位，可发生转移甚至致死，严重威胁患者健康。氨基酮戊酸光动力疗法（ALA-PDT）作为药械联合的局部微创肿瘤物理疗法，在cSCC诊疗中具有较高应用价值和前景。本文系统回顾国内外ALA-PDT治疗cSCC的诊疗现状和机制研究，分析当前技术瓶颈与临床挑战，深入探讨未来优化方向，以期推动该疗法的个体化、精准化、规范化应用。

关键词: 癌, 鳞状细胞, 光化学疗法, 氨基酮戊酸, 治疗, 治疗机制

Abstract: 【Abstract】 Cutaneous squamous cell carcinoma （cSCC） predominantly occurs on sun-exposed areas such as the head and face, with the potential for metastasis and even fatality, posing a serious threat to patient health. Aminolevulinic acid-based photodynamic therapy （ALA-PDT）, as a locally minimally invasive physical antitumor therapy that combines a photosensitizer with a medical device, holds considerable clinical value and promise in the diagnosis and treatment of cSCC. This article systematically reviews the current status of and mechanistic research on ALA-PDT for cSCC in China and other countries, analyzes current technical bottlenecks and clinical challenges, and explores future optimization strategies, with the aim of promoting the individualized, precise, and standardized application of ALA-PDT for cSCC.

Key words: Carcinoma, squamous cell, Photochemotherapy, Aminolevulinic acid, Therapy, Therapeutic mechanism

张国龙赵子君. 氨基酮戊酸光动力疗法治疗皮肤鳞状细胞癌的现状、挑战和思考[J]. 中华皮肤科杂志, 2026,59(7):626-631. doi:10.35541/cjd.20260178

Zhang Guolong, Zhao Zijun. Aminolevulinic acid-based photodynamic therapy for cutaneous squamous cell carcinoma: current status, challenges, and perspectives[J]. Chinese Journal of Dermatology, 2026, 59(7): 626-631.doi:10.35541/cjd.20260178

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氨基酮戊酸光动力疗法治疗皮肤鳞状细胞癌的现状、挑战和思考

Aminolevulinic acid-based photodynamic therapy for cutaneous squamous cell carcinoma: current status, challenges, and perspectives

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