诱发性银屑病样动物模型的研究进展

doi:10.35541/cjd.20250129

中华皮肤科杂志 ›› 2026, e20250129.doi: 10.35541/cjd.20250129

诱发性银屑病样动物模型的研究进展

王永兴¹,丁媛²

¹新疆医科大学研究生学院，乌鲁木齐 830054；²新疆维吾尔自治区人民医院皮肤性病科新疆皮肤性病临床医学研究中心新疆皮肤病研究重点实验室，乌鲁木齐 830054

收稿日期:2025-03-13 修回日期:2026-02-22 发布日期:2026-05-12
通讯作者: 丁媛 E-mail:dydyuan@126.com
基金资助:
国家自然科学基金（82360621）；新疆维吾尔自治区“天山英才”培养计划（2023TSYCCX0047）

Induced psoriasis-like animal models

Wang Yongxing¹, Ding Yuan²

¹Graduate School of Xinjiang Medical University, Urumqi 830054, China; ²Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatology and Venereology, Xinjiang Key Laboratory of Dermatology Research, Urumqi 830054, China

Received:2025-03-13 Revised:2026-02-22 Published:2026-05-12
Contact: Ding Yuan E-mail:dydyuan@126.com
Supported by:
National Natural Science Foundation of China （82360621）; Xinjiang Uygur Autonomous Region Tianshan Talent Traning Program （2023TSYCCX0047）

摘要/Abstract

摘要： 【摘要】动物模型是银屑病研究的重要工具，其中诱发性银屑病样动物模型被广泛使用，诱发方式包括局部外用、注射和口服，如局部外用咪喹莫特、腹腔注射甘露聚糖、口服普萘洛尔等诱发的银屑病样动物模型。这些模型与人类银屑病皮损高度相似，在可重复性、稳定性和实用性等方面都有显著优势，已成为研究银屑病发病机制、探索治疗靶点和评价疗效的重要工具。本文综述目前诱发性银屑病样动物模型的研究进展，并分析存在的问题。

关键词: 银屑病, 模型, 动物, 咪喹莫特, 普萘洛尔, 甘露聚糖类, 细胞因子

Abstract: 【Abstract】 Animal models are crucial tools in psoriasis research, with induced psoriasis-like models being widely employed. Induction methods include topical application, injection, and oral administration, such as psoriasis like animal models induced by the topical application of imiquimod, intraperitoneal injection of mannan, and oral administration of propranolol. These models exhibit high similarity to human psoriatic lesions and offer significant advantages in reproducibility, stability, and practicality. They have become essential tools for investigating psoriasis pathogenesis, exploring therapeutic targets, and evaluating treatment efficacy. This review summarizes current research progress on induced psoriasis?like animal models and analyzes existing challenges.

Key words: Psoriasis, Models, animal, Imiquimod, Propranolol, Mannans, Cytokines

王永兴丁媛. 诱发性银屑病样动物模型的研究进展[J]. 中华皮肤科杂志, 2026,e20250129. doi:10.35541/cjd.20250129

Wang Yongxing, Ding Yuan. Induced psoriasis-like animal models[J]. Chinese Journal of Dermatology,2026,e20250129. doi:10.35541/cjd.20250129

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诱发性银屑病样动物模型的研究进展

Induced psoriasis-like animal models

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