色氨酸和精氨酸代谢对免疫反应的调控机制及其在银屑病发病中的作用研究进展

doi:10.35541/cjd.20240377

中华皮肤科杂志 ›› 2026, e20240377.doi: 10.35541/cjd.20240377

色氨酸和精氨酸代谢对免疫反应的调控机制及其在银屑病发病中的作用研究进展

郭澜晋红中

中国医学科学院北京协和医学院北京协和医院皮肤科疑难重症及罕见病国家重点实验室国家皮肤与免疫疾病临床医学研究中心，北京 100730

收稿日期:2024-07-16 修回日期:2025-08-10 发布日期:2026-03-11
通讯作者: 晋红中 E-mail:jinhongzhong@263.net
基金资助:
北京市自然科学基金资助（7242109）；中央高水平医院临床科研业务费（2022-PUMCH-B-092）；北京市临床重点专科项目；国家临床重点专科建设项目

Tryptophan and arginine metabolism in immune regulation and their role in the pathogenesis of psoriasis

Guo Lan, Jin Hongzhong

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China

Received:2024-07-16 Revised:2025-08-10 Published:2026-03-11
Contact: Jin Hongzhong E-mail:jinhongzhong@263.net
Supported by:
Beijing Natural Science Foundation （7242109）; National High Level Hospital Clinical Research Funding （2022-PUMCH-B-092）; Beijing Key Clinical Specialty Construction Project; National Key Clinical Specialty Project of China

摘要/Abstract

摘要： 【摘要】机体可以通过氨基酸代谢调控免疫应答，在自身免疫性疾病的发病过程中发挥作用。银屑病是一种常见的慢性自身免疫性皮肤疾病，其发病机制涉及到树突细胞、T细胞等免疫细胞的调节失衡。越来越多的证据表明，银屑病中特定氨基酸的水平失调及代谢过程与其发病机制之间互相关联，其中研究相对较多的是色氨酸和精氨酸的代谢。色氨酸和精氨酸代谢通过调控免疫应答在银屑病发病中起到重要作用，亦可能提供新的治疗靶点。本综述分别对色氨酸和精氨酸的代谢过程及对免疫系统的调节作用进行总结，并阐述其在银屑病发病作用中的研究进展，旨在以新的视角理解银屑病的发病机制，有助于提供疾病干预的新思路。

关键词: 氨基酸代谢, 色氨酸, 精氨酸, 免疫调控, 银屑病

Abstract: 【Abstract】 Amino acid metabolism plays a key role in regulating immune responses and in the pathogenesis of autoimmune diseases. Psoriasis is a common chronic autoimmune skin disease, whose pathogenesis involves the imbalance of dendritic cells, T cells and other immune cells. Growing evidence indicates that the imbalance of certain amino acids and their metabolic process in psoriasis are related to the pathogenesis of psoriasis, with tryptophan and arginine metabolism being relatively well-studied. They play important roles in the pathogenesis of psoriasis by regulating immune response, and may also provide new therapeutic targets. This review summarizes the metabolic process of tryptophan and arginine as well as their regulatory effects on the immune system, and discusses the current research advances regarding their roles in the pathogenesis of psoriasis, aiming to provide a novel perspective on the pathogenesis of psoriasis, potentially facilitating new approaches for disease intervention.

Key words: Amino acid metabolism, Tryptophan, Arginine, Immune regulation, Psoriasis

郭澜晋红中. 色氨酸和精氨酸代谢对免疫反应的调控机制及其在银屑病发病中的作用研究进展[J]. 中华皮肤科杂志, 2026,e20240377. doi:10.35541/cjd.20240377

Guo Lan, Jin Hongzhong. Tryptophan and arginine metabolism in immune regulation and their role in the pathogenesis of psoriasis[J]. Chinese Journal of Dermatology,2026,e20240377. doi:10.35541/cjd.20240377

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色氨酸和精氨酸代谢对免疫反应的调控机制及其在银屑病发病中的作用研究进展

Tryptophan and arginine metabolism in immune regulation and their role in the pathogenesis of psoriasis

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