毛囊黑素干细胞在白发中的研究进展

doi:10.35541/cjd.20230153

中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (2): 182-185.doi: 10.35541/cjd.20230153

毛囊黑素干细胞在白发中的研究进展

汪锋夏汝山

南京医科大学附属无锡市第二人民医院皮肤科，无锡 214000

收稿日期:2023-03-20 修回日期:2024-08-20 发布日期:2025-02-07
通讯作者: 夏汝山 E-mail:wxeyxrs@163.com

Roles of melanocyte stem cells in hair follicles in hair graying

Wang Feng, Xia Rushan

Department of Dermatology, the Affiliated Wuxi No.2 People′s Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu, China

Received:2023-03-20 Revised:2024-08-20 Published:2025-02-07
Contact: Xia Rushan E-mail:wxeyxrs@163.com

摘要/Abstract

摘要： 【摘要】白发是一种常见的与衰老相关的现象，毛囊中黑素干细胞的过度分化在白发发生发展中的作用逐渐被关注。同时毛囊的周期性循环为研究干细胞提供了一个较好的模型，并且随着小鼠模型以及细胞移植技术的不断发展，人们对于白发以及衰老的认知也在稳步深入，但依旧存在许多疑问。本文围绕黑素干细胞阐述其来源、生物学特征以及信号通路，并进一步说明其与白发之间的联系以及部分药物在毛发色素再沉着中的作用。

关键词: 毛囊, 干细胞, 黑素细胞, 白发, 信号传导通路, 毛发色素再沉着

Abstract: 【Abstract】 Hair graying is a common phenomenon associated with aging, and the excessive differentiation of melanocyte stem cells in hair follicles has gradually gained attention for its role in the occurrence and development of hair graying. The cyclical nature of hair follicles provides an excellent model for studying stem cells. With the continuous development of mouse models and cell transplantation technologies, the understanding of hair graying and aging has been steadily deepening, though many questions remain unanswered. This review focuses on the origins and biological characteristics of melanocyte stem cells and their related signaling pathways. It further explains the relationship between melanocyte stem cells and hair graying, as well as the role of some drugs in hair repigmentation.

Key words: Hair follicle, Stem cells, Melanocytes, Hair graying, Signal transducing pathway, Hair repigmentation

汪锋夏汝山. 毛囊黑素干细胞在白发中的研究进展[J]. 中华皮肤科杂志, 2025,58(2):182-185. doi:10.35541/cjd.20230153

Wang Feng, Xia Rushan . Roles of melanocyte stem cells in hair follicles in hair graying[J]. Chinese Journal of Dermatology, 2025, 58(2): 182-185.doi:10.35541/cjd.20230153

参考文献 39

［1］	O'Sullivan J, Nicu C, Picard M, et al. The biology of human hair greying［J］. Biol Rev Camb Philos Soc, 2021,96（1）:107⁃128. doi: 10.1111/brv.12648.
［2］	Le Coz M, Aktary Z, Watanabe N, et al. Targeted knockout of β⁃catenin in adult melanocyte stem cells using a mouse line, Dct::CreER（T2）, results in disrupted stem cell renewal and pigmentation defects［J］. J Invest Dermatol, 2021,141（5）:1363⁃1366.e9. doi: 10.1016/j.jid.2020.08.025.
［3］	Wu S, Yu Y, Liu C, et al. Single⁃cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying［J］. Cell Discov, 2022,8（1）:49. doi: 10.1038/s41421⁃022⁃00394⁃2.
［4］	Han X, Chang L, Qiu Z, et al. Micro⁃injury induces hair regeneration and vitiligo repigmentation through Wnt/β⁃catenin pathway［J］. Stem Cells Dev, 2022,31（5⁃6）:111⁃118. doi: 10. 1089/scd.2021.0276.
［5］	Bedogni B, Paus R. Hair（y） matters in melanoma biology［J］. Trends Mol Med, 2020,26（5）:441⁃449. doi: 10.1016/j.molmed. 2020.02.005.
［6］	Hsu YC, Fuchs E. Building and maintaining the skin［J］. Cold Spring Harb Perspect Biol, 2022,14（7）:a040840. doi: 10.1101/cshperspect.a040840.
［7］	Nishimura EK, Jordan SA, Oshima H, et al. Dominant role of the niche in melanocyte stem⁃cell fate determination［J］. Nature, 2002,416（6883）:854⁃860. doi: 10.1038/416854a.
［8］	Li A. The biology of melanocyte and melanocyte stem cell［J］. Acta Biochim Biophys Sin （Shanghai）, 2014,46（4）:255⁃260. doi: 10.1093/abbs/gmt145.
［9］	Lang D, Lu MM, Huang L, et al. Pax3 functions at a nodal point in melanocyte stem cell differentiation［J］. Nature, 2005,433（7028）:884⁃887. doi: 10.1038/nature03292.
［10］	Joshi SS, Tandukar B, Pan L, et al. CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties［J］. PLoS Genet, 2019,15（4）:e1008034. doi: 10.1371/journal.pgen.1008034.
［11］	Tandukar B, Kalapurakal E, Hornyak TJ. B6⁃Dct⁃H2BGFP bitransgenic mice: a standardized mouse model for in vivo characterization of melanocyte development and stem cell differentiation［J］. Pigment Cell Melanoma Res, 2021,34（5）:905⁃917. doi: 10.1111/pcmr.12959.
［12］	Wang ZH, Liu LP, Zheng YW. Melanocyte stem cells in skin diseases and their potential in cell⁃based therapy［J］. Histol Histopathol, 2022,37（10）:937⁃953. doi: 10.14670/HH⁃18⁃470.
［13］	Harshuk⁃Shabso S, Dressler H, Niehrs C, et al. Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock［J］. Nat Commun, 2020,11（1）:5114. doi: 10.1038/s41467⁃020⁃18643⁃x.
［14］	Li H, Hou L. Regulation of melanocyte stem cell behavior by the niche microenvironment［J］. Pigment Cell Melanoma Res, 2018,31（5）:556⁃569. doi: 10.1111/pcmr.12701.
［15］	Rabbani P, Takeo M, Chou W, et al. Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration［J］. Cell, 2011,145（6）:941⁃955. doi: 10.1016/j.cell.2011.05.004.
［16］	Guo H, Xing Y, Liu Y, et al. Wnt/β⁃catenin signaling pathway activates melanocyte stem cells in vitro and in vivo［J］. J Dermatol Sci, 2016,83（1）:45⁃51. doi: 10.1016/j.jdermsci.2016. 04.005.
［17］	Yamada T, Hasegawa S, Inoue Y, et al. Wnt/β⁃catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB⁃induced epidermal pigmentation［J］. J Invest Dermatol, 2013,133（12）:2753⁃2762. doi: 10.1038/jid.2013.235.
［18］	Infarinato NR, Stewart KS, Yang Y, et al. BMP signaling: at the gate between activated melanocyte stem cells and differentiation［J］. Genes Dev, 2020,34（23⁃24）:1713⁃1734. doi: 10.1101/gad. 340281.120.
［19］	Sun Q, Lee W, Hu H, et al. Dedifferentiation maintains melanocyte stem cells in a dynamic niche［J］. Nature, 2023,616（7958）:774⁃782. doi: 10.1038/s41586⁃023⁃05960⁃6.
［20］	Richter LR, Wan Q, Wen D, et al. Targeted delivery of notch inhibitor attenuates obesity⁃induced glucose intolerance and liver fibrosis［J］. ACS Nano, 2020,14（6）:6878⁃6886. doi: 10. 1021/acsnano.0c01007.
［21］	Kumano K, Masuda S, Sata M, et al. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis［J］. Pigment Cell Melanoma Res, 2008,21（1）:70⁃78. doi: 10.1111/j.1755⁃148X.2007.00423.x.
［22］	Moriyama M, Osawa M, Mak SS, et al. Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells［J］. J Cell Biol, 2006,173（3）:333⁃339. doi: 10.1083/jcb.200509084.
［23］	Lu Z, Xie Y, Huang H, et al. Hair follicle stem cells regulate retinoid metabolism to maintain the self⁃renewal niche for melanocyte stem cells［J］. Elife, 2020,9:e52712. doi: 10.7554/eLife.52712.
［24］	VanBuren CA, Everts HB. Vitamin A in skin and hair: an update［J］. Nutrients, 2022,14（14）:2952. doi: 10.3390/nu14142952.
［25］	Valluet A, Druillennec S, Barbotin C, et al. B⁃Raf and C⁃Raf are required for melanocyte stem cell self⁃maintenance［J］. Cell Rep, 2012,2（4）:774⁃780. doi: 10.1016/j.celrep.2012.08.020.
［26］	Peng D, Fu M, Wang M, et al. Targeting TGF⁃β signal transduction for fibrosis and cancer therapy［J］. Mol Cancer, 2022,21（1）:104. doi: 10.1186/s12943⁃022⁃01569⁃x.
［27］	Nishimura EK, Suzuki M, Igras V, et al. Key roles for transforming growth factor beta in melanocyte stem cell maintenance［J］. Cell Stem Cell, 2010,6（2）:130⁃140. doi: 10. 1016/j.stem.2009.12.010.
［28］	Chang CY, Pasolli HA, Giannopoulou EG, et al. NFIB is a governor of epithelial⁃melanocyte stem cell behaviour in a shared niche［J］. Nature, 2013,495（7439）:98⁃102. doi: 10.1038/nature 11847.
［29］	Takeo M, Lee W, Rabbani P, et al. EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling［J］. Cell Rep, 2016,15（6）:1291⁃1302. doi: 10.1016/j.celrep. 2016.04.006.
［30］	Yu Y, Zhang X, Liu F, et al. A stress⁃induced miR⁃31⁃CLOCK⁃ERK pathway is a key driver and therapeutic target for skin aging［J］. Nat Aging, 2021,1（9）:795⁃809. doi: 10.1038/s43587⁃021⁃00094⁃8.
［31］	Zhang B, Ma S, Rachmin I, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells［J］. Nature, 2020,577（7792）:676⁃681. doi: 10.1038/s41586⁃020⁃1935⁃3.
［32］	Yale K, Juhasz M, Atanaskova Mesinkovska N. Medication⁃induced repigmentation of gray hair: a systematic review［J］. Skin Appendage Disord, 2020,6（1）:1⁃10. doi: 10.1159/00050 4414.
［33］	Anderson ZT, Palmer JW, Idris MI, et al. Topical RT1640 treatment effectively reverses gray hair and stem cell loss in a mouse model of radiation⁃induced canities［J］. Pigment Cell Melanoma Res, 2021,34（1）:89⁃100. doi: 10.1111/pcmr.12913.
［34］	Nagase K, Inoue T, Narisawa Y. Manifest hair repigmentation associated with etretinate therapy［J］. J Dermatol, 2017,44（3）:e34⁃e35. doi: 10.1111/1346⁃8138.13514.
［35］	Manson G, Marabelle A, Houot R. Hair repigmentation with anti⁃PD⁃1 and anti⁃PD⁃L1 immunotherapy: a novel hypothesis［J］. JAMA Dermatol, 2018,154（1）:113. doi: 10.1001/jamadermatol. 2017.4421.
［36］	Almeida Scalvino S, Chapelle A, Hajem N, et al. Efficacy of an agonist of α⁃MSH, the palmitoyl tetrapeptide⁃20, in hair pigmentation［J］. Int J Cosmet Sci, 2018,40（5）:516⁃524. doi: 10.1111/ics.12494.
［37］	Taguchi N, Yuriguchi M, Ando T, et al. Flavonoids with two OH groups in the B⁃ring promote pigmented hair regeneration［J］. Biol Pharm Bull, 2019,42（9）:1446⁃1449. doi: 10.1248/bpb.b19⁃00295.
［38］	Liu LP, Li YM, Guo NN, et al. Therapeutic potential of patient iPSC⁃Derived iMelanocytes in autologous transplantation［J］. Cell Rep, 2019,27（2）:455⁃466.e5. doi: 10.1016/j.celrep.2019. 03.046.
［39］	Cancedda R, Mastrogiacomo M. Transit amplifying cells （TACs）: a still not fully understood cell population［J］. Front Bioeng Biotechnol, 2023,11:1189225. doi: 10.3389/fbioe.2023. 1189225.

[1]	李明李妍李邻峰. Janus激酶抑制剂在中重度特应性皮炎中的应用进展[J]. 中华皮肤科杂志, 2025, 0(3): 20220342-e0220342.
[2]	许焯红胡煜顾恒. 间充质干细胞来源的外泌体在皮肤病中的作用[J]. 中华皮肤科杂志, 2025, 0(3): 20220881-e20220881.
[3]	袁梦莎赵涛刘玲. 脂肪干细胞基质胶临床应用进展[J]. 中华皮肤科杂志, 2025, 0(3): 20240300-e20240300.
[4]	李倩雯廖志锴乐悦段博林耿朦朦雷铁池. 抗氧化剂Tempol抑制氧化应激状态下免疫诱导白癜风小鼠尾部皮肤色素脱失[J]. 中华皮肤科杂志, 2025, 58(2): 126-131.
[5]	郭伟楠王俊霞陈慧郝军峰李冰卫静宜赵涛. 自体脂肪干细胞胶填充治疗凹陷性痤疮瘢痕疗效观察[J]. 中华皮肤科杂志, 2025, 58(2): 167-169.
[6]	陈佳希易秀莉李春英李舒丽. 叶酸对体外培养的黑色素细胞氧化应激损伤的保护作用研究[J]. 中华皮肤科杂志, 2024, 57(6): 547-552.
[7]	鞠强李嘉祺. [开放获取] 寻常痤疮再认识：从发病机制到治疗策略[J]. 中华皮肤科杂志, 2024, 57(4): 289-294.
[8]	李嘉祺梁梦晨吴心怡张秋婧李思彤莫小辉鞠强. 中度寻常痤疮患者皮损毛囊内表皮葡萄球菌基因序列分型的初步研究[J]. 中华皮肤科杂志, 2024, 57(4): 295-301.
[9]	戴叶芹宋秀祖. 毛囊及毛囊细胞移植在白癜风治疗中的应用进展[J]. 中华皮肤科杂志, 2024, 0(3): 20230274-e0230274.
[10]	张钰得王红娟康晓静. 干细胞治疗白癜风的基础及临床研究进展[J]. 中华皮肤科杂志, 2024, 0(3): 20240127-e20240127.
[11]	陈钰虹吕中法. 毛囊生长周期调控的机制进展[J]. 中华皮肤科杂志, 2024, 0(3): 20230226-e20230226.
[12]	杨洁刘莉萍. 单细胞测序在毛发相关研究中的应用[J]. 中华皮肤科杂志, 2024, 0(3): 20230292-e20230292.
[13]	王涛武毅靳虹戴叶芹彭建中许爱娥宋秀祖. 回顾性分析电解白发联合毛囊移植治疗25例毛发部位白癜风的疗效[J]. 中华皮肤科杂志, 2024, 57(1): 46-49.
[14]	马晶晶亢盼郭森坚哲李春英李舒丽. 转录因子TFAP2B在健康人及白癜风患者表皮黑色素细胞中的表达模式[J]. 中华皮肤科杂志, 2024, 57(1): 29-33.
[15]	李春英陈健儒李舒丽. 白癜风代谢重塑：进展和未来[J]. 中华皮肤科杂志, 2024, 57(1): 8-11.

毛囊黑素干细胞在白发中的研究进展

Roles of melanocyte stem cells in hair follicles in hair graying

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 39

相关文章 15

Metrics

本文评价

推荐阅读 10