中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (4): 313-317.doi: 10.35541/cjd.20201111
沙姗姗1 李军2 陶娟1
收稿日期:
2020-11-20
修回日期:
2021-01-12
发布日期:
2021-03-31
通讯作者:
陶娟
E-mail:tjhappy@126.com
基金资助:
Sha Shanshan1, Li Jun2, Tao Juan1
Received:
2020-11-20
Revised:
2021-01-12
Published:
2021-03-31
Contact:
Tao Juan
E-mail:tjhappy@126.com
Supported by:
摘要: 【摘要】 黑素瘤是高度恶性的免疫原性肿瘤,尽管以免疫检查点抑制剂为代表的免疫治疗可显著提高转移性黑素瘤患者的生存率,但仍有近半数患者对免疫治疗产生耐受和抵抗,且免疫相关不良反应发生率高。本文聚焦目前黑素瘤免疫治疗存在的耐受、抵抗及免疫相关不良反应等关键难点,总结相应的对策与研究进展。通过干预黑素瘤免疫抑制性微环境、筛选精准的生物标记物及优化免疫治疗联合策略等能够帮助解决免疫治疗耐受和抵抗的问题,同时传统免疫治疗与纳米技术的结合也可大幅减少免疫相关不良反应的发生。未来,对肿瘤免疫微环境更为广泛和深入的研究将有助于探索黑素瘤免疫治疗的最佳方式。
沙姗姗 李军 陶娟. 黑素瘤免疫治疗的难点及对策[J]. 中华皮肤科杂志, 2021,54(4):313-317. doi:10.35541/cjd.20201111
Sha Shanshan, Li Jun, Tao Juan. Melanoma immunotherapy: difficulties and strategies[J]. Chinese Journal of Dermatology, 2021, 54(4): 313-317.doi:10.35541/cjd.20201111
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