中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (9): 662-662.

• 病例报告 • 上一篇    下一篇

羟基脲相关多发疣状皮肤角化合并皮肤鳞状细胞癌一例

贾近博1,林尽染2,陈国梁3,徐金华4,陈明华2   

  1. 1. 上海市复旦大学附属华山医院
    2. 复旦大学附属华山医院皮肤科
    3. 上海复旦大学附属华山医院皮肤科
    4. 上海市复旦大学附属华山医院皮肤科
  • 收稿日期:2010-01-11 修回日期:2010-03-03 发布日期:2010-09-10
  • 通讯作者: 陈明华 E-mail:cmh626@hotmail.com

A case of hydroxycarbamide-associated multiple verrucous keratosis complicated by cutaneous squamous cell carcinoma

  • Received:2010-01-11 Revised:2010-03-03 Published:2010-09-10

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摘要：

报告1例长期使用羟基脲引起的多发疣状皮肤角化并发皮肤鳞癌。患者女，55岁，以双手足多发黄色至黑褐色疣状角化丘疹、斑块，左手掌溃疡性肿块为主要表现。患者有骨髓纤维化病史8年，长期服用羟基脲。左手掌肿块经组织病理证实为皮肤鳞癌。给予左前臂截肢术，其余皮损外用咪喹莫特治疗。

关键词: 羟基脲, 疣状角化, 鳞癌, 皮肤

Abstract:

We report a case of hydroxyurea-associated multiple verrucous keratoses and squamous cell carcinoma of the skin. A 55-year-old female patient presented with multiple yellowish to brownish verrucous keratotic papules, plaques on both hands and feet, ulcerative mass on left palm. She had a history of bone marrow fibrosis that was well controlled by hydroxyurea therapy for 8 years. Histopathology of ulcerative mass on left palm showed cutaneous squamous cell carcinoma. The patient subsequently underwent left forearm amputation, and the remainder of the lesions were treated by imiquimod.

Key words: Hydroxyurea, Verrucous keratoses, Squamous cell carcinoma, Skin