脂质代谢在皮肤恶性肿瘤发生发展及诊疗中的研究进展

doi:10.35541/cjd.20240137

中华皮肤科杂志 ›› 2026, Vol. 59 ›› Issue (4): 379-382.doi: 10.35541/cjd.20240137

脂质代谢在皮肤恶性肿瘤发生发展及诊疗中的研究进展

薛舒月¹ 李婷婷² 康晓静²

¹新疆医科大学研究生学院，乌鲁木齐 830001；²新疆维吾尔自治区人民医院皮肤性病科新疆皮肤性病临床医学研究中心新疆皮肤病研究重点实验室，乌鲁木齐 830001

收稿日期:2024-03-18 修回日期:2025-02-21 发布日期:2026-04-03
通讯作者: 康晓静 E-mail:drkangxj666@163.com
基金资助:
新疆维吾尔自治区重点研发计划项目（2024B03039-1）

Lipid metabolism in the occurrence, development, diagnosis and treatment of cutaneous malignancies

Xue Shuyue¹, Li Tingting², Kang Xiaojing²

¹Graduate School of Xinjiang Medical University, Urumqi 830001, China; ²Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatology and Venereology, Xinjiang Key Laboratory of Dermatology Research, Urumqi 830001, China

Received:2024-03-18 Revised:2025-02-21 Published:2026-04-03
Contact: Kang Xiaojing E-mail:drkangxj666@163.com
Supported by:
Xinjiang Uygur Autonomous Region Key R & D Program（2024B03039-1）

摘要/Abstract

摘要： 【摘要】皮肤恶性肿瘤发病率和死亡率逐年升高，侵袭性高、预后差，严重危及患者生命。脂质代谢在肿瘤的发生发展中发挥重要角色，为肿瘤细胞的生命活动提供必要的物质基础。脂质代谢的异常会干扰炎症因子、代谢物及信号传导通路，进而导致基因和蛋白的异常表达，从而加剧肿瘤细胞的恶性转化、侵袭及转移。近年来，对脂质代谢与皮肤恶性肿瘤的相关研究不断深入，靶向脂质代谢治疗在针对皮肤恶性肿瘤的治疗中占有重要地位。本文综述脂质代谢在黑色素瘤、鳞状细胞癌、卡波西肉瘤和基底细胞癌发生发展中的分子机制，并介绍靶向脂质代谢的诊疗策略。

关键词: 皮肤恶性肿瘤, 脂质代谢, 黑色素瘤, 鳞状细胞癌, 卡波西肉瘤, 基底细胞癌, 发病机制, 靶向治疗

Abstract: 【Abstract】 The incidence and mortality of skin malignant tumors have been increasing year by year, characterized by high invasiveness and poor prognosis, posing a serious threat to patients' lives. Lipid metabolism plays a critical role in tumor occurrence and development by providing essential material support for tumor cell activities. Dysregulation of lipid metabolism can interfere with inflammatory mediators, metabolites, and signaling pathways, leading to abnormal gene and protein expression, thereby promoting the malignant transformation, invasion, and metastasis of tumor cells. In recent years, research on lipid metabolism in skin malignant tumors has deepened, and therapies targeting lipid metabolism have gained increasing importance in their treatment. This review summarizes the molecular mechanisms of lipid metabolism in the occurrence and development of melanoma, squamous cell carcinoma, Kaposi sarcoma, and basal cell carcinoma, and outlines diagnostic and therapeutic strategies targeting lipid metabolism.

Key words: Skin malignant tumors, lipid metabolism, melanoma, squeous cell carcinoma, Kaposi sarcoma, basal cell carcinoma, pathogenesis, targeted treatment

薛舒月李婷婷康晓静. 脂质代谢在皮肤恶性肿瘤发生发展及诊疗中的研究进展 [J]. 中华皮肤科杂志, 2026,59(4):379-382. doi:10.35541/cjd.20240137

Xue Shuyue, Li Tingting, Kang Xiaojing. Lipid metabolism in the occurrence, development, diagnosis and treatment of cutaneous malignancies[J]. Chinese Journal of Dermatology, 2026, 59(4): 379-382.doi:10.35541/cjd.20240137

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脂质代谢在皮肤恶性肿瘤发生发展及诊疗中的研究进展

Lipid metabolism in the occurrence, development, diagnosis and treatment of cutaneous malignancies

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