皮肤衰老和常见皮肤病中成纤维细胞异质性与功能的研究进展

doi:10.35541/cjd.20240283

中华皮肤科杂志 ›› 2026, e20240283.doi: 10.35541/cjd.20240283

皮肤衰老和常见皮肤病中成纤维细胞异质性与功能的研究进展

彭恋淇周诺娅董恩柱饶真琦索慧男陶娟

华中科技大学同济医学院附属协和医院皮肤科，武汉 430022

收稿日期:2024-05-24 修回日期:2024-12-28 发布日期:2026-06-29
通讯作者: 索慧男

Advances in fibroblast heterogeneity and function in skin aging and common skin diseases

Peng Lianqi, Zhou Nuoya, Dong Enzhu, Rao Zhenqi, Suo Huinan, Tao Juan

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Received:2024-05-24 Revised:2024-12-28 Published:2026-06-29

摘要/Abstract

摘要： 【摘要】成纤维细胞是皮肤组织中重要的组成细胞，一方面参与损伤修复，维持皮肤的健康与完整性；另一方面，在多种皮肤疾病中，成纤维细胞发挥了多样且复杂的作用。近年来单细胞RNA测序等技术的发展极大地推动了成纤维细胞异质性与功能的研究，这种异质性在发育起源、解剖位置和发病机制等方面均有所体现。本文总结了皮肤衰老和常见皮肤病中成纤维细胞的异质性和功能，以深入了解相关发生机制，并为临床诊疗提供新的线索。

关键词: 成纤维细胞, 皮肤衰老, 皮肤疾病, 异质性, 亚群, 发病机制

Abstract: 【Abstract】 Fibroblasts are an essential cell type in skin tissues. On the one hand, fibroblasts play a central role in tissue repair, maintaining skin health and integrity; on the other hand, they play diverse and complex roles in the pathogenesis of various skin diseases. In recent years, the development of single?cell RNA sequencing and other technologies has greatly promoted research on fibroblast heterogeneity and function, as reflected in developmental origins, anatomical locations and disease pathogenesis. This review summarizes the heterogeneity and function of fibroblasts in skin aging and common skin diseases, aiming to deepen the understanding of related mechanisms and provide insights for clinical diagnosis and treatment.

Key words: Fibroblasts, Skin aging, Skin diseases, Heterogeneity, Subgroup, Pathogenesis

彭恋淇周诺娅董恩柱饶真琦索慧男陶娟. 皮肤衰老和常见皮肤病中成纤维细胞异质性与功能的研究进展[J]. 中华皮肤科杂志, 2026,e20240283. doi:10.35541/cjd.20240283

Peng Lianqi, Zhou Nuoya, Dong Enzhu, Rao Zhenqi, Suo Huinan, Tao Juan. Advances in fibroblast heterogeneity and function in skin aging and common skin diseases[J]. Chinese Journal of Dermatology,2026,e20240283. doi:10.35541/cjd.20240283

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皮肤衰老和常见皮肤病中成纤维细胞异质性与功能的研究进展

Advances in fibroblast heterogeneity and function in skin aging and common skin diseases

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