纳米医学在恶性黑色素瘤中的诊断和治疗新策略

doi:10.35541/cjd.20230109

中华皮肤科杂志 ›› 2024, e20230109.doi: 10.35541/cjd.20230109

纳米医学在恶性黑色素瘤中的诊断和治疗新策略

严可心张韡宋昊徐秀莲

中国医学科学院北京协和医学院皮肤病医院皮肤病研究所病理科，南京 210042

收稿日期:2023-02-28 修回日期:2023-12-09 发布日期:2024-03-11
通讯作者: 徐秀莲 E-mail:xxlqjl@sina.com
基金资助:
国家自然科学基金（81772916、82103470）；江苏省自然科学基金（BK20171132）；西藏自治区自然科学基金［XZ2021ZR-ZY12（Z）］

Nanomedicine: a new strategy for the diagnosis and treatment of melanoma

Yan Kexin, Xu Xiulian

Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Received:2023-02-28 Revised:2023-12-09 Published:2024-03-11
Contact: Xu Xiulian E-mail:xxlqjl@sina.com
Supported by:
National Natural Science Foundation of China （81772916, 82103470）; Jiangsu Natural Science Foundation （BK20171132）;Natural Science Foundation of Xizang Autonomous Region（XZ2021ZR-ZY12［Z］）

摘要/Abstract

摘要： 【摘要】恶性黑色素瘤在皮肤癌中最具侵袭性，其诊断和治疗仍是一个艰巨的挑战。目前，晚期黑色素瘤的治疗方法有免疫治疗、化学疗法、分子靶向治疗、放射治疗、光动力疗法、光热疗法、基因治疗等，但是它们的治疗效果有限。新兴的纳米材料在癌症的诊断和治疗中，能够提高药物的生物利用度，并且精准靶向癌细胞。本文综述用于恶性黑色素瘤的诊断和不同治疗方法中的一些纳米颗粒的最新研究进展。

关键词: 黑色素瘤, 纳米医学, 脂质体, 磁性纳米粒子, 诊断, 治疗

Abstract: 【Abstract】 Melanoma is the most aggressive skin cancers, and its diagnosis and treatment remain a formidable challenge. At present, treatment methods for advanced melanoma include immunotherapy, chemotherapy, molecular targeted therapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, etc., but their efficacy is limited. Application of emerging nanomaterials in the diagnosis and treatment of cancers can improve the drug bioavailability and cancer cell-targeted precision. This review summarizes the latest research progress on some nanoparticles used for the diagnosis and different treatments of melanoma.

Key words: Melanoma, Nanomedicine, Liposomes, Magnetite nanoparticles, Diagnosis, Therapy

严可心张韡宋昊徐秀莲. 纳米医学在恶性黑色素瘤中的诊断和治疗新策略[J]. 中华皮肤科杂志, 2024,e20230109. doi:10.35541/cjd.20230109

Yan Kexin, Xu Xiulian. Nanomedicine: a new strategy for the diagnosis and treatment of melanoma[J]. Chinese Journal of Dermatology,2024,e20230109. doi:10.35541/cjd.20230109

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纳米医学在恶性黑色素瘤中的诊断和治疗新策略

Nanomedicine: a new strategy for the diagnosis and treatment of melanoma

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