中华皮肤科杂志 ›› 2022, e20220028.doi: 10.35541/cjd.20220028

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慢性手部湿疹的治疗进展

白璐    楚妍    刘园园    朱才勇   

  1. 解放军陆军第八十集团军医院皮肤病科,潍坊  261021
  • 收稿日期:2022-01-12 修回日期:2022-03-08 发布日期:2022-05-06
  • 通讯作者: 朱才勇 E-mail:caiyongpfk@sina.com

Treatment of chronic hand eczema

Bai Lu, Chu Yan, Liu Yuanyuan, Zhu Caiyong   

  1. Department of Dermatology, The Hospital of No.80 Group Army of PLA, Weifang 261021, Shandong, China
  • Received:2022-01-12 Revised:2022-03-08 Published:2022-05-06
  • Contact: Zhu Caiyong E-mail:caiyongpfk@sina.com

摘要: 【摘要】 目前外用糖皮质激素仍是慢性手部湿疹的一线治疗药物,治疗无效的中重度慢性手部湿疹需系统用药。传统治疗包括糖皮质激素、抗组胺药、维A酸类药物及免疫抑制剂等。近年来,JAK抑制剂、磷酸二酯酶4抑制剂、生物制剂、他汀类药物、噻吗洛尔、日光光动力等治疗慢性手部湿疹取得了一定的进展。本综述总结了基础治疗、局部用药、物理治疗和系统治疗等应用于慢性手部湿疹的新进展。

关键词: 湿疹, 分子靶向治疗, 磷酸二酯酶4抑制剂, 治疗, 慢性手部湿疹, 度普利尤单抗, JAK抑制剂

Abstract: 【Abstract】 Currently, topical glucocorticoids are still the first-line treatment of chronic hand eczema, while systematic treatment is required for moderate to severe chronic hand eczema with no response to topical corticosteroids. Traditional treatments include glucocorticoids, antihistamines, retinoids, immunosuppressants, etc. In recent years, some progress has been made in the treatment of chronic hand eczema with Janus kinase inhibitors, phosphodiesterase 4 inhibitors, biological agents, statins, timolol, daylight photodynamic therapy, etc. This review summarizes recent advances in the treatment of chronic hand eczema, including basic therapy, topical treatment, physical therapy and systemic therapy.

Key words: Eczema, Molecular targeted therapy, Phosphodiesterase 4 inhibitors, Therapy, Chronic hand eczema, Dupilumab, Janus kinase inhibitors

引用本文

白璐 楚妍 刘园园 朱才勇. 慢性手部湿疹的治疗进展[J]. 中华皮肤科杂志, 2022,e20220028. doi:10.35541/cjd.20220028

Bai Lu, Chu Yan, Liu Yuanyuan, Zhu Caiyong. Treatment of chronic hand eczema[J]. Chinese Journal of Dermatology,2022,e20220028. doi:10.35541/cjd.20220028