中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (7): 449-451.

• 论著 •    下一篇

SAPHO综合征22例分析

杨青1,屈丽娜1,史本青2,于长平3,田洪青1,彭建2,张福仁4   

  1. 1. 山东省皮肤病性病防治研究所
    2.
    3. 山东省皮肤病防治研究所 250022
    4. 济南山东省皮肤病防治研究所 250022
  • 收稿日期:2009-11-20 修回日期:2009-12-15 出版日期:2010-07-15 发布日期:2010-07-13
  • 通讯作者: 杨青 E-mail:yangqing79@126.com

SAPHO syndrome: clinical analysis of 22 cases

  • Received:2009-11-20 Revised:2009-12-15 Online:2010-07-15 Published:2010-07-13

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摘要：

目的 探讨SAPHO综合征的临床特点。方法 对22例SAPHO综合征患者的临床资料进行登记并分析。结果 22例中男7例，女15例，皮损出现的平均年龄为45岁，骨关节受累平均年龄为44岁。皮损表现为掌跖脓疱病者21例，暴发性痤疮者1例。骨关节受累中前胸壁受累19例，外周关节受累4例，骶髂关节受累2例。10例患者关节受累早于皮损发生，9例患者皮损早于关节受累，3例患者皮损与关节受累同时出现。关节受累与皮损出现平均间隔2.7年，最长达20年。结论 皮肤科就诊的SAPHO综合征患者以中年女性多见。掌跖脓疱病和前胸壁骨关节受累是最常见的临床表现。

关键词: [关键词] SAPHO综合征, 掌跖脓疱病, 痤疮, 骨关节损害

Abstract:

Objective To investigate the clinical features of SAPHO syndrome. Methods Clinical data of 22 cases of SAPHO syndrome were analysed. Results There were 7 males and 15 females among the 22 patients. The average age at onset of cutaneous and osteoarticular lesions was 45 years and 44 years, respectively. Of the 22 patients, 21 had palmoplantar pustulosis and 1 had acne fulminans. Anterior chest wall（ACW） was involved in 19 patients, peripheral joints in 4 patients and sacroiliac joints in 2 patients. Osteoarticular manifestations occurred prior to the onset of skin lesions in 10 cases, after that in 9 cases, and simultaneously in 3 cases. The mean interval between the onset of cutaneous and osteoarticular lesions was 2.7 years and the longest interval was 20 years. Conclusions Middle-aged females predominate in patients with SAPHO syndrome seen in dermatological clinics. Palmoplantar pustulosis and ACW involvement are the most common clinical manifestations of SAPHO syndrome.

Key words: [Key words] SAPHO syndrome, palmoplantar pustolosis, acne, osteoarticular lesion