中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (3): 146-147.

• 论著 • 上一篇    下一篇

银屑病皮损及非皮损中垂体腺苷酸环化酶激活肽及其受体的研究

张力军1, 杨雪琴2, 孟如松2, 李铀2, 江丽2   

  1. 1. 第四军医大学西京医院皮肤科 西安 710033;
    2. 北京空军总医院皮肤科
  • 收稿日期:2003-10-30 出版日期:2005-03-15 发布日期:2005-03-15

Expression of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor in Psoriatic Lesions and Non-lesional Skins

ZHANG Li-jun1, YANG Xue-qin2, MENG Ru-song2, LI You2, JIANG Li2   

  1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China
  • Received:2003-10-30 Online:2005-03-15 Published:2005-03-15

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摘要： 目的 探讨垂体腺苷酸环化酶激活肽(PACAP)及其受体(PACAP-R)在银屑病发病中的意义。方法 采用免疫组化的方法研究寻常性银屑病患者皮损及非皮损部位PACAP及PACAP-R的原位表达情况。结果 银屑病患者皮损部位PACAP及PACAP-R的原位表达均明显低于非皮损部位,表现为皮损组PACAP及PACAP-R的面积密度及平均吸光度值显著低于正常人对照组(均为P<0.01);与正常人相比,非皮损部位PACAP及PACAP-R的原位表达也呈下调表达,即非皮损组的PACAP及PACAP-R的面积密度及平均吸光度值明显低于正常人对照组(P<0.05)。结论 PACAP及PACAP-R在银屑病皮损中下调表达,提示PACAP可能与银屑病表皮细胞的过度增殖有关。

关键词: 银屑病, 垂体腺苷酸环化酶激活肽

Abstract: Objective To investigate the effects of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor (PACAP-R) on the pathogenesis of psoriasis.Methods The expression of PACAP and PACAP-R in the skin from 10 normal controls,25 psoriatic lesions and non-lesional skins was measured by immunohistochemical technique.Results The expression of PACAP and PACAP-R was significantly lower in the psoriatic lesional skins than that of the non-lesional skins.The area density and mean absorbance of PACAP and PACAP-R in the lesional skins were significantly lower compared with those in the non-lesional skins (P<0.01).The area density and mean absorbance of PACAP and PACAP-R in the non-lesional skins were significantly lower compared with those in the normal controls (P<0.05).Conclusions The down-expression of PACAP and PACAP-R in psoriatic skin suggests that PACAP might be related to the hyperproliferation of psoriatic keratinocytes.

Key words: Psoriasis, Pituitary adenylate cyclase activating polypeptide