中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (3): 148-150.

• 论著 • 上一篇    下一篇

银屑病患者外周血肝细胞生长因子和粒细胞-巨噬细胞集落刺激因子水平改变

许冰1, 王勇刚1, 吴炜2, 吴灵娇2   

  1. 1. 浙江大学医学院附属第一医院皮肤科 杭州 310003;
    2. 浙江大学医学院附属第一医院传染病研究所 杭州 310003
  • 收稿日期:2004-01-07 出版日期:2005-03-15 发布日期:2005-03-15

Serum Levels of Hepatocyte Growth Factor and Granulocyte Macrophage-Colony Stimulating Factor in Patients with Psoriasis

XU Bing1, WANG Yong-gang1, WU Wei2, WU Ling-jiao2   

  1. Department of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2004-01-07 Online:2005-03-15 Published:2005-03-15

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摘要： 目的 探讨肝细胞生长因子(HGF)和粒细胞-巨噬细胞集落刺激因子(GM-CSF)与银屑病的关系。方法 采用双抗体夹心酶联免疫吸附试验(ELISA)检测寻常性银屑病患者和正常人血清中HGF和GM-CSF水平。结果 进行期寻常性银屑病患者血清中HGF水平明显高于静止期及正常人对照(P<0.01),而静止期患者血清中HGF水平与正常人对照比较差异无统计学意义(P>0.05);进行期银屑病患者血清中GM-CSF水平明显高于正常人对照及静止期(P<0.01),静止期患者血清中GM-CSF水平亦高于正常人对照(P<0.05);进行期泛发性与局限性皮损患者之间血清HGF及GM-CSF水平差异均无统计学意义;患者血清HGF和GM-CSF水平与PASI计分均呈正相关(分别为r=0.38和r=0.30,P<0.002和P<0.02)。结论 寻常性银屑病患者外周血循环HGF和GM-CSF水平明显增高,HGF和GM-CSF可能参与银屑病发病。

关键词: 银屑病, 肝细胞生长因子, 粒细胞巨噬细胞集落刺激因子

Abstract: Objective To investigate the serum levels of hepatocyte growth factor (HGF) and granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with psoriasis.Methods Serum samples were collected from 68 patients with psoriasis vulgaris and 42 healthy controls.The serum concentrations of HGF and GM-CSF were measured by a dual antibody sandwich enzyme-linked immunosorbent assay (ELISA).Clinical severity of psoriasis vulgaris was assessed by psoriasis area and severity index (PASI) score.Results Serum concentration of HGF of patients with psoriasis vulgaris in progressive stage (653.35±109.26 pg/mL) was significantly higher than that of the normal controls (353.85±162.63 pg/mL) (P<0.01),and of the patients in stable stage (362.35±120.40 pg/mL) (P<0.01).The serum concentration of HGF between the patients in stable stage and normal controls was not significantly different (P>0.05).The serum concentration of GM-CSF was significantly higher in the patients with psoriasis vulgaris of progressive stage (115.95±25.72 pg/mL) than that in the patients of stable stage (68.28±24.22 pg/mL) (P<0.01),and in healthy controls (53.11±25.92 pg/mL) (P<0.01).And serum concentration of GM-CSF was significantly increased in the patients of stable stage compared with normal controls (P<0.05).Between the progressive stage patients with generalized lesions and those with localized lesions,no significant differences were observed in serum HGF,and GM-CSF.There were significant correlations between PASI score with serum concentration of HGF,and with that of GM-CSF (r=0.38 and r=0.30,P<0.002 and P<0.02,respectively).Conclusions The Results indicate that serum concentrations of HGF and GM-CSF are significantly increased in the patients with psoriasis vulgaris,and that serum concentrations of HGF and GM-CSF correlate significantly with the activity and severity of psoriasis.These data suggest that HGF and GM-CSF may be involved in the pathogenesis of psoriasis.

Key words: Psoriasis, Hepatocyte growth factor, Granulocyte-macrophage-colony-stimulating factor