中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (6): 363-365.

• 论著 • 上一篇    下一篇

周期蛋白依赖激酶抑制因子p21WAF1/CIP1在银屑病表皮中高表达

张晓艳1, 马圣清1, 柳惠图2   

  1. 1. 北京医科大学第一临床学院皮肤科 100034;
    2. 北京师范大学生物系 100034
  • 收稿日期:1997-09-23 修回日期:1998-02-16 出版日期:1998-12-15 发布日期:1998-12-15
  • 基金资助:
    国家自然科学基金(39388002, 39200024)

Overexpression of p21WAF1 CIP1——inhibitor of Cyclin-Dependent Kinase in Psoriatic Epidermis

Zhang Niaoyan1, Ma Shengqing1, Liu Huitu2   

  1. Department of Dermatology, The first Hospital of Beijing Medical University, 100034
  • Received:1997-09-23 Revised:1998-02-16 Online:1998-12-15 Published:1998-12-15

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摘要： 目的 探讨p21WAF1/CIP1与银屑病发病的关系.方法 通过核酸杂交和免疫组织化学的方法检测了12例斑块型银屑病和5例正常人表皮中p21WAF1/CIP1的表达.结果 银屑病表皮中p21WAF1/CIP1的表达位于表皮全层, 较正常表皮明显增强, 正常人表皮中其表达位于表皮上部.结论 p21WAF1/CIP1可能与正常表皮细胞的分化关系更密切, 在银屑病表皮细胞的异常分化调节中可能发挥作用.

关键词: 银屑病, p21WAF1/CIP1

Abstract: Objective To observe the relationship between p21and development of psoriasis.Methods The expression of p21WAF1/CIP1 in twelve psoriatic and five normal epidermis was studied by dot hyhridization, in situ hvbridization and immunohistochemistry.Results In psoriatic epidermis, the expression of p21WAF1/CIP1, was in whole layers of epidermis, and was significantly inereased eompared with that of normal skin. In normal epidermis, its expression was in upper laver of epidermis.Conclusion These results indicate thai p21WAF1/CIP1 might be assoeiated with differentiation of normal keralinoevtes and might play a role in abnormal differentiation of psoriatic keratonoeyles.

Key words: Psoriasis, p21WAF1/CIP1