中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (6): 366-367.

• 论著 • 上一篇    下一篇

组氨酸光氧化试验检测吡哌酸和诺氟沙星的光敏性

阎春林, 廖康煌, 胡跃, 徐昱   

  1. 上海医科大学附属华山医院皮肤科 200040
  • 收稿日期:1997-12-25 修回日期:1998-05-25 出版日期:1998-12-15 发布日期:1998-12-15
  • 基金资助:
    卫生部科研基金资助课题

Histidine Photooxidation in Assessment of Photosensitizing Agents

Yan Chunlin, Liao Kanghuang, Hu Yue   

  1. Department of Dermatology, Huashan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1997-12-25 Revised:1998-05-25 Online:1998-12-15 Published:1998-12-15

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摘要： 目的 建立体外检测光敏物质的模型 方法 采用组氨酸光氧化试验检测了吡哌酸和诺氟沙星引起的光敏反应.并观察了UVA剂量和药物浓度对光敏反应强度的影响 结果 经不同剂量UVA照射后, 吡哌酸和诺氟沙星药品溶液中的组氨酸浓度有不同程度的降低.不同浓度药物致组氨酸光氧化反应程度间有显著性差异(P<0.01);不同剂量UVA致组氨酸光氧化反应程度间有显著性差异(P<0.01) 结论 吡哌酸和诺氟沙星均引起组氨酸光氧化分解, UVA剂量增加和药物浓度增加都导致光敏反应增强.

关键词: 光敏感药, 组氨酸光氧化试验

Abstract: Objective To establish a model for assessment of photosensitizing agents in vitrO.Methods Hislidine photooxidation method was employed.Histidine was irradiated wilh UVA in the presence of pipemidic acid and norfloxacin.Then the remaining histidine was assessed Pauly reaction.Results Histidine concenlration in pipemidic acid solution and norfloxacin solution decrdased after UVA irradiation The photodegradation rate of histidine increased with the increase of UVA dosage and drug concenlration.Conclusion Both pipemidie acid and norfloxacin cause photoxidation of histidine.

Key words: Photosensitizing agents, Photooxidation histidine