中华皮肤科杂志 ›› 2024, e0220740.doi: 10.35541/cjd.20220740

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[开放获取]    TYK2抑制剂治疗斑块状银屑病的作用机制和临床研究进展

袁立燕    余晓玲    王晓华    杨斌   

  1. 南方医科大学皮肤病医院皮肤科,广州  510091
  • 收稿日期:2022-10-21 修回日期:2023-07-31 发布日期:2024-05-17
  • 通讯作者: 杨斌 E-mail:yangbin@smu.edu.cn

TYK2 inhibitors for plaque psoriasis: mechanism of action and advances in clinical research

Yuan Liyan, Yu Xiaoling, Wang Xiaohua, Yang Bin   

  1. Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou 510091, China
  • Received:2022-10-21 Revised:2023-07-31 Published:2024-05-17
  • Contact: Yang Bin E-mail:yangbin@smu.edu.cn

摘要: 【摘要】 随着对银屑病发病机制的深入了解,靶向Janus激酶(JAK)-酪氨酸激酶(TYK)2关键通路的小分子靶向药物日益受到关注。TYK2相关通路在银屑病发病机制中发挥重要作用,并且该通路不参与调控广泛的生物学效应,是银屑病高效安全的潜在治疗靶点之一。如何提高TYK2抑制剂的选择性和特异性以减少其他通路抑制带来的相关不良反应是近年来TYK2抑制剂药物研发的重点方向之一。本文对TYK2通路在银屑病发病机制中的作用、TYK2抑制剂的作用方式(竞争性抑制或变构抑制)以及相关最新临床研究进展作一综述。

关键词: 银屑病, 信号传导, Janus激酶类, TYK2激酶, 氘可来昔替尼

Abstract: 【Abstract】 With the deepening understanding of the pathogenesis of psoriasis, small-molecule drugs targeting the key Janus kinase (JAK)-tyrosine kinase (TYK)2 pathway have gained increasing interest. TYK2-related pathways play an important role in the pathogenesis of psoriasis, while they are not involved in modulating broad biological effects, making them one of the potential therapeutic targets for the efficient and safe treatment of psoriasis. How to improve the selectivity and specificity of TYK2 inhibitors to minimize adverse reactions associated with the inhibition of other pathways has been one of the key directions for drug development of TYK2 inhibitors in recent years. This review summarizes the role of TYK2 pathway in the pathogenesis of psoriasis, the modes of action of TYK2 inhibitors (competitive or allosteric inhibition), and the latest clinical research progress.

Key words: Psoriasis, Signal transduction, Janus kinases, TYK2 kinase, Deucravacitinib

引用本文

袁立燕 余晓玲 王晓华 杨斌. [开放获取]    TYK2抑制剂治疗斑块状银屑病的作用机制和临床研究进展[J]. 中华皮肤科杂志, 2024,e0220740. doi:10.35541/cjd.20220740

Yuan Liyan, Yu Xiaoling, Wang Xiaohua, Yang Bin. TYK2 inhibitors for plaque psoriasis: mechanism of action and advances in clinical research[J]. Chinese Journal of Dermatology,2024,e0220740. doi:10.35541/cjd.20220740