中华皮肤科杂志 ›› 2023, e20210672.doi: 10.35541/cjd.20210672

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银屑病生物制剂治疗对结核感染的影响及机制

汤自洁1    王睿2    李承新1   

  1. 1解放军医学院  解放军总医院第一医学中心皮肤科,北京  100853;2解放军总医院第一医学中心皮肤科,北京  100853
  • 收稿日期:2021-09-14 修回日期:2022-09-05 发布日期:2023-11-30
  • 通讯作者: 李承新 E-mail:chengxinderm@163.com
  • 基金资助:
    国家自然科学基金(81972936)

Effect of biotherapy for psoriasis on tuberculosis infection and relevant mechanisms

Tang Zijie1, Wang Rui2, Li Chengxin1   

  1. 1Medical School of Chinese PLA, Department of Dermatology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; 2Department of Dermatology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  • Received:2021-09-14 Revised:2022-09-05 Published:2023-11-30
  • Contact: Li Chengxin E-mail:chengxinderm@163.com
  • Supported by:
    National Natural Science Foundation of China(81972936)

摘要: 【摘要】 近年生物制剂在银屑病,尤其是在重度难治性及特殊类型银屑病的治疗中发挥了积极作用,但其安全性也日益受到关注,尤以结核感染风险为著。本文针对不同作用靶点的生物制剂对结核的影响及其机制进行综述,为患者选择合适的生物制剂提供理论依据。

关键词: 银屑病, 生物制剂, 结核, 潜伏性结核, 生物治疗

Abstract: 【Abstract】 In recent years, biological agents have played an active role in the treatment of psoriasis, especially for severe, refractory and special subtypes of psoriasis. However, their safety has attracted increasing attention, especially the risk of tuberculosis infection. This review summarizes the effect of biological agents with different targets on tuberculosis infection and relevant mechanisms, aiming to provide a theoretical basis for psoriasis patients to choose appropriate biotherapy.

Key words: Psoriasis, Biological agents, Tuberculosis, Latent tuberculosis, Biotherapy

引用本文

汤自洁 王睿 李承新. 银屑病生物制剂治疗对结核感染的影响及机制[J]. 中华皮肤科杂志, 2023,e20210672. doi:10.35541/cjd.20210672

Tang Zijie, Wang Rui, Li Chengxin. Effect of biotherapy for psoriasis on tuberculosis infection and relevant mechanisms[J]. Chinese Journal of Dermatology,2023,e20210672. doi:10.35541/cjd.20210672