中华皮肤科杂志 ›› 2024, Vol. 57 ›› Issue (10): 962-966.doi: 10.35541/cjd.20220709

• 综述 • 上一篇    

克立硼罗软膏在皮肤科中的应用进展

杨思燕1    马琳2    张斌2   

  1. 1郑州大学附属儿童医院  河南省儿童医院郑州儿童医院皮肤科  河南省儿科疾病临床医学研究中心,郑州  450018;2国家儿童医学中心  首都医科大学附属北京儿童医院皮肤科,北京  100045
  • 收稿日期:2022-10-11 修回日期:2023-12-19 发布日期:2024-09-29
  • 通讯作者: 张斌;马琳 E-mail:dr.binzhang@163.com; bch_maleen@aliyun.com
  • 基金资助:
    北京市自然科学基金(7222058);河南省儿科疾病临床医学研究中心开放课题项目(YJZX202209);国家区域医疗中心开放课题项目(NRMC0101)

Application of crisaborole ointment in dermatology

Yang Siyan1, Ma Lin2, Zhang Bin2   

  1. 1Department of Dermatology, Henan Clinical Research Center of Childhood Diseases, Children′s Hospital Affiliated of Zhengzhou University, Henan Children′s Hospital Zhengzhou Children′s Hospital, Zhengzhou 450018, China; 2Department of Dermatology, Beijing Children′s Hospital, Capital Medical University, National Center for Children′s Health, Beijing 100045, China
  • Received:2022-10-11 Revised:2023-12-19 Published:2024-09-29
  • Contact: Zhang Bin;Ma Lin E-mail:dr.binzhang@163.com; bch_maleen@aliyun.com
  • Supported by:
    Beijing Natural Science Foundation (7222058); Open Project of Henan Clinical Research Center of Childhood Diseases (YJZX202209); National Regional Medical Center Opening Project (NRMC0101)

摘要: 【摘要】 克立硼罗是一种磷酸二酯酶4抑制剂,已在国内被批准用于轻度至中度特应性皮炎患者的治疗。此外,克立硼罗软膏也被报道成功治疗多种炎症性皮肤疾病。本文综述克立硼罗的作用机制及其在特应性皮炎、银屑病、白癜风、脂溢性皮炎、炎性线状疣状表皮痣、慢性单纯性苔藓、色素性痒疹、斑秃、浆细胞性龟头炎、扁平苔藓等皮肤疾病治疗中的研究进展。

关键词: 环核苷酸磷酸二酯酶类, 4型, 磷酸二酯酶4抑制剂, 克立硼罗软膏, 皮肤疾病, 治疗, 皮炎, 特应性, 银屑病, 白癜风

Abstract: 【Abstract】 Crisaborole ointment, a phosphodiesterase-4 inhibitor, has been approved for the treatment of mild to moderate atopic dermatitis in China. In addition, crisaborole has been reported for the successful treatment of other inflammatory skin disorders. This review summarizes mechanisms of action of crisaborole and its application to the treatment of atopic dermatitis, psoriasis, vitiligo, seborrheic dermatitis, inflammatory linear verrucous epidermal nevus, lichen simplex chronicus, prurigo pigmentosa, alopecia areata, plasma cell balanitis, and lichen planus.

Key words: Cyclic nucleotide phosphodiesterases, type 4, Phosphodiesterase-4 inhibitor, Crisaborole ointment, Skin diseases, Therapy, Dermatitis, atopic, Psoriasis, Vitiligo

引用本文

杨思燕 马琳 张斌. 克立硼罗软膏在皮肤科中的应用进展[J]. 中华皮肤科杂志, 2024,57(10):962-966. doi:10.35541/cjd.20220709

Yang Siyan, Ma Lin, Zhang Bin. Application of crisaborole ointment in dermatology[J]. Chinese Journal of Dermatology, 2024, 57(10): 962-966.doi:10.35541/cjd.20220709