中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (6): 522-526.doi: 10.35541/cjd.20200797

• Meta分析 • 上一篇    下一篇

苄星青霉素联合头孢曲松对早期梅毒血清快速血浆反应素环状卡片试验/甲苯胺红不加热血清试验结果影响的Meta分析

卢改会1    李涛2    刘学伟1   

  1. 1河南中医药大学第一附属医院皮肤科，郑州  450000；2河南中医药大学第一附属医院一期临床研究病房，郑州  450000
  • 收稿日期:2020-08-10 修回日期:2021-02-20 发布日期:2021-05-31
  • 通讯作者: 李涛 E-mail:jianhe190@126.com
  • 作者简介:2021年6月底见刊
  • 基金资助:
    河南省自然科学基金（212300410190）；河南省中医药科学研究专项课题（2019JDZX2029）

Effect of benzathine penicillin combined with ceftriaxone on the results of rapid plasma reagin circle card test/toluidine red unheated serum test in the treatment of early syphilis: a meta-analysis

Lu Gaihui1, Li Tao2, Liu Xuewei1   

  1. 1Department of Dermatology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China; 2Phase I Clinical Research Ward, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
  • Received:2020-08-10 Revised:2021-02-20 Published:2021-05-31
  • Contact: Li Tao E-mail:jianhe190@126.com
  • Supported by:
    Natural Science Foundation of Henan Province （212300410190）; Special Project of Scientific Research on Traditional Chinese Medicine in Henan Province （2019JDZX2029）

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摘要： 【摘要】 目的 系统评价苄星青霉素联合头孢曲松治疗早期梅毒对血清快速血浆反应素环状卡片试验/甲苯胺红不加热血清试验（RPR/TRUST）转阴率的疗效。方法 检索PubMed、Web of science、Embase、Cochrane、中国知网、万方、维普数据库中关于苄星青霉素联合头孢曲松治疗早期梅毒的病例对照研究。使用Newcastle-Ottawa量表（NOS）评估纳入研究文献的质量，使用RevMan5.3软件分析患者RPR/TRUST转阴率。结果 共纳入14个病例对照研究1 160例梅毒患者，联合组585例，单用组575例。结果显示，联合组血清RPR/TRUST转阴率明显高于单用组［OR = 3.70，95% CI（2.71，5.06），P < 0.001］。按随访时间进行亚组分析，联合治疗组在治疗后3个月［OR = 3.68，95% CI（2.26，5.98），P < 0.001］、6个月［OR = 3.11，95% CI（2.26，4.27），P < 0.001］及12个月时［OR = 4.35，95% CI（2.81，6.73），P < 0.001］RPR/TRUST转阴率均高于单用组。结论 与苄星青霉素相比，苄星青霉素联合头孢曲松治疗早期梅毒能更有效地促进血清RPR/TRUST转阴。

关键词: 梅毒, 苄星青霉素G, 头孢曲松, 药物疗法, 联合, 梅毒血清诊断, Meta分析

Abstract: 【Abstract】 Objective To systematically evaluate the efficacy of benzathine penicillin combined with ceftriaxone on the negative conversion rate of the rapid plasma reagin circle card test/toluidine red unheated serum test （RPR/TRUST） in the treatment of early syphilis. Methods According to the search strategy, online databases （PubMed, Web of science, Embase, Cochrane Library, CNKI, Wanfang and VIP） were searched for case-control studies on benzathine penicillin combined with ceftriaxone in the treatment of early syphilis. The Newcastle Ottawa scale （NOS） was used to evaluate the quality of the included articles, and the RevMan5.3 software to analyze the negative conversion rate of RPR/TRUST. Results A total of 14 case-control studies were included, including 1 160 syphilis patients （585 in the combination treatment group and 575 in the benzathine penicillin alone group）. According to the meta-analysis, the negative conversion rate of serum RPR/TRUST was significantly higher in the combination treatment group than in the benzathine penicillin alone group （OR = 3.70, 95% CI ［2.71, 5.06］, P＜0.001）. Subgroup analysis based on the follow-up duration, the negative conversion rate of serum RPR/TRUST was also significantly higher in the combination treatment group than in the benzathine penicillin alone group after 3-month （OR = 3.68, 95% CI ［2.26, 5.98］, P＜0.001）, 6-month （OR = 3.11, 95% CI ［2.26, 4.27］, P＜0.001） and 12-month treatment （OR = 4.35, 95% CI ［2.81, 6.73］, P＜0.001）. Conclusion Compared with benzathine penicillin, benzathine penicillin combined with ceftriaxone can more effectively promote serum RPR/TRUST to turn negative in the treatment of early syphilis.

Key words: Syphilis, Penicillin G benzathine, Ceftriaxone, Drug therapy, combination, Syphilis serodiagnosis, Meta analysis