中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (12): 1122-1126.doi: 10.35541/cjd.20200528
• 综述 • 上一篇
陈绍椿 刘经纬 周可 尹跃平
收稿日期:
2020-06-01
修回日期:
2021-01-30
发布日期:
2022-12-05
通讯作者:
陈绍椿;尹跃平
E-mail:chensc@ncstdlc.org; yinyp@ncstdlc.org
基金资助:
Chen Shaochun, Liu Jingwei, Zhou Ke, Yin Yueping
Received:
2020-06-01
Revised:
2021-01-30
Published:
2022-12-05
Contact:
Chen Shaochun; Yin Yueping
E-mail:chensc@ncstdlc.org; yinyp@ncstdlc.org
Supported by:
摘要: 【摘要】 淋球菌耐药问题是性传播疾病防控中面临的巨大挑战,近年来在世界范围包括我国流行的头孢曲松耐药淋病奈瑟菌株FC428使耐药问题更加严峻。该菌株因含新型镶嵌结构的penA基因而对头孢曲松高度耐药,且已在全球广泛传播。为更好地了解FC428的特征,控制其进一步传播,本文综述其起源、传播、主要分子特征、耐药机制、检测方法以及临床治疗和耐药监测的策略。
陈绍椿 刘经纬 周可 尹跃平. 头孢曲松耐药淋病奈瑟菌株FC428的流行、耐药机制及应对策略[J]. 中华皮肤科杂志, 2022,55(12):1122-1126. doi:10.35541/cjd.20200528
Chen Shaochun, Liu Jingwei, Zhou Ke, Yin Yueping. Ceftriaxone-resistant Neisseria gonorrhoeae strain FC428: prevalence, resistance mechanisms and control strategies[J]. Chinese Journal of Dermatology, 2022, 55(12): 1122-1126.doi:10.35541/cjd.20200528
[1] | Rowley J, Vander Hoorn S, Korenromp E, et al. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016[J]. Bull World Health Organ, 2019,97(8):548⁃562P. doi: 10.2471/BLT.18.228486. |
[2] | Yue XL, Gong XD, Li J, et al. Gonorrhea in China, 2018[J/OL]. Int J Dermatol Venereol, 2019,2(2):65⁃69[2020⁃06⁃24]. https://journals.lww.com/ijdv/Fulltext/2019/06000/Gonorrhea_in_China,_2018.1.aspx. doi: 10.1097/JD9.0000000000000008. |
[3] | Nakayama S, Shimuta K, Furubayashi K, et al. New ceftriaxone⁃ and multidrug⁃resistant Neisseria gonorrhoeae strain with a novel mosaic pena gene isolated in Japan[J]. Antimicrob Agents Chemother, 2016,60(7):4339⁃4341. doi: 10.1128/AAC. 00504⁃16. |
[4] | Ohnishi M, Golparian D, Shimuta K, et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high⁃level resistance to ceftriaxone[J]. Antimicrob Agents Chemother, 2011,55(7):3538⁃3545. doi: 10.1128/AAC.00325⁃11. |
[5] | Deguchi T, Yasuda M, Hatazaki K, et al. New clinical strain of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone, Japan[J]. Emerg Infect Dis, 2016,22(1):142⁃144. doi: 10.3201/eid2201.150868. |
[6] | Unemo M, Golparian D, Nicholas R, et al. High⁃level cefixime⁃ and ceftriaxone⁃resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure[J]. Antimicrob Agents Chemother, 2012,56(3):1273⁃1280. doi: 10.1128/AAC.05760⁃11. |
[7] | Lahra MM, Ryder N, Whiley DM. A new multidrug⁃resistant strain of Neisseria gonorrhoeae in Australia[J]. N Engl J Med, 2014,371(19):1850⁃1851. doi: 10.1056/NEJMc1408109. |
[8] | Cherdtrakulkiat T, Wongsurawat T, Jenjaroenpun P, et al. Complete genome sequences of three Neisseria gonorrhoeae isolates from Thailand with multidrug resistance and multilocus sequence type 1903[J]. Microbiol Resour Announc, 2020,9(19). doi: 10.1128/MRA.00198⁃20. |
[9] | Chen SC, Han Y, Yuan LF, et al. Identification of internationally disseminated ceftriaxone⁃resistant Neisseria gonorrhoeae strain FC428, China[J]. Emerg Infect Dis, 2019,25(7):1427⁃1429. doi: 10.3201/eid2507.190172. |
[10] | Lahra MM, Martin I, Demczuk W, et al. Cooperative recognition of internationally disseminated ceftriaxone⁃resistant Neisseria gonorrhoeae strain[J]. Emerg Infect Dis, 2018,24(4):735⁃740. doi: 10.3201/eid2404.171873. |
[11] | Lefebvre B, Martin I, Demczuk W, et al. Ceftriaxone⁃resistant Neisseria gonorrhoeae, Canada, 2017. Emerg Infect Dis, 2018,24(2):381⁃383. doi: 10.3201/eid2402.171756. |
[12] | Terkelsen D, Tolstrup J, Johnsen CH, et al. Multidrug⁃resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017[J]. Euro Surveill,2017,22(42):17⁃00659. doi: 10.2807/1560⁃7917.ES.2017.22.42.17⁃00659. |
[13] | Golparian D, Rose L, Lynam A, et al. Multidrug⁃resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018[J]. Euro Surveill, 2018,23(47):1800617. doi: 10.2807/1560⁃7917.ES.2018.23.47.1800617. |
[14] | Eyre DW, Town K, Street T, et al. Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018. Euro Surveill, 2019, 24(10):1900147. doi: 10.2807/1560⁃7917.ES.2019.24.10.1900 147. |
[15] | Ko K, Chio M, Goh SS, et al. First case of ceftriaxone⁃resistant multidrug⁃resistant Neisseria gonorrhoeae in Singapore[J]. Antimicrob Agents Chemother, 2019,63(5):e02624⁃18. doi: 10. 1128/AAC.02624⁃18. |
[16] | Poncin T, Merimeche M, Braille A, et al. Two cases of multidrug⁃resistant Neisseria gonorrhoeae related to travel in south⁃eastern Asia, France, June 2019[J]. Euro Surveill, 2019,24(36):1900528. doi: 10.2807/1560⁃7917.ES.2019.24.36.1900528. |
[17] | Lee K, Nakayama SI, Osawa K, et al. Clonal expansion and spread of the ceftriaxone⁃resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates[J]. J Antimicrob Chemother, 2019,74(7):1812⁃1819. doi: 10. 1093/jac/dkz129. |
[18] | Berenger BM, Demczuk W, Gratrix J, et al. Genetic characterization and enhanced surveillance of ceftriaxone⁃resistant Neisseria gonorrhoeae Strain, Alberta, Canada, 2018. Emerg Infect Dis, 2019,25(9):1660⁃1667. doi: 10.3201/eid2509. 190407. |
[19] | Chen SC, Yuan LF, Zhu XY, et al. Sustained transmission of the ceftriaxone⁃resistant Neisseria gonorrhoeae FC428 clone in China[J]. J Antimicrob Chemother, 2020,75(9):2499⁃2502. doi: 10.1093/jac/dkaa196. |
[20] | Yang Y, Yang Y, Martin I, et al. NG⁃STAR genotypes are associated with MDR in Neisseria gonorrhoeae isolates collected in 2017 in Shanghai[J]. J Antimicrob Chemother, 2020,75(3):566⁃570. doi: 10.1093/jac/dkz471. |
[21] | Yang F, Zhang H, Chen Y, et al. Detection and analysis of two cases of the internationally spreading ceftriaxone⁃resistant Neisseria gonorrhoeae FC428 clone in China[J]. J Antimicrob Chemother, 2019,74(12):3635⁃3636. doi: 10.1093/jac/dkz384. |
[22] | Wang H, Wang Y, Yong G, et al. Emergence and genomic characterization of the ceftriaxone⁃resistant Neisseria gonorrhoeae FC428 clone in Chengdu, China[J]. J Antimicrob Chemother, 2020,75(9):2495⁃2498. doi: 10.1093/jac/dkaa123. |
[23] | Yuan Q, Li Y, Xiu L, et al. Identification of multidrug⁃resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017-2018[J]. Emerg Microbes Infect, 2019, 8(1):1546⁃1549. doi: 10.1080/22221751. 2019.1681242. |
[24] | Jolley KA, Maiden MC. BIGSdb: Scalable analysis of bacterial genome variation at the population level[J]. BMC Bioinformatics, 2010,11:595. doi: 10.1186/1471⁃2105⁃11⁃595. |
[25] | Martin IM, Ison CA, Aanensen DM, et al. Rapid sequence⁃based identification of gonococcal transmission clusters in a large metropolitan area[J]. J Infect Dis, 2004,189(8):1497⁃1505. doi: 10.1086/383047. |
[26] | Demczuk W, Sidhu S, Unemo M, et al. Neisseria gonorrhoeae sequence typing for antimicrobial resistance, a novel antimicrobial resistance multilocus typing scheme for tracking global dissemination of N. gonorrhoeae strains[J]. J Clin Microbiol, 2017,55(5):1454⁃1468. doi: 10.1128/JCM.001 00⁃17. |
[27] | Tomberg J, Unemo M, Ohnishi M, et al. Identification of amino acids conferring high⁃level resistance to expanded⁃spectrum cephalosporins in the penA gene from Neisseria gonorrhoeae strain H041[J]. Antimicrob Agents Chemother, 2013,57(7):3029⁃3036. doi: 10.1128/AAC.00093⁃13. |
[28] | Zhou K, Chen SC, Yang F, et al. Impact of the gonococcal FC428 penA allele 60.001 on ceftriaxone resistance and biological fitness[J]. Emerg Microbes Infect, 2020,9(1):1219⁃1229. doi: 10.1080/22221751.2020.1773325. |
[29] | Shimuta K, Igawa G, Yasuda M, et al. A real⁃time PCR assay for detecting a penA mutation associated with ceftriaxone resistance in Neisseria gonorrhoeae[J]. J Glob Antimicrob Resist, 2019,19:46⁃49. doi: 10.1016/j.jgar.2019.02.011. |
[30] | Whiley DM, Mhango L, Jennison AV, et al. Direct detection of penA gene associated with ceftriaxone⁃resistant Neisseria gonorrhoeae FC428 strain by using PCR[J]. Emerg Infect Dis, 2018,24(8):1573⁃1575. doi: 10.3201/eid2408.180295. |
[31] | Xiu L, Zhang C, Li Y, et al. High⁃resolution melting analysis for rapid detection of the internationally spreading ceftriaxone⁃resistant Neisseria gonorrhoeae FC428 clone[J]. J Antimicrob Chemother, 2020,75(1):106⁃109. doi: 10.1093/jac/dkz395. |
[32] | Shimuta K, Nakayama SI, Takahashi H, et al. A loop⁃mediated isothermal amplification assay targeting Neisseria gonorrhoeae penA⁃60.001[J]. Antimicrob Agents Chemother, 2019,64(1):e01663⁃19. doi: 10.1128/AAC.01663⁃19. |
[33] | Li Y, Xiu L, Liu J, et al. A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi⁃PCR coupled with mass spectrometry[J]. J Antimicrob Chemother, 2020,75(10):2817⁃2825. doi: 10.1093/jac/dkaa269. |
[34] | Xiu L, Yuan Q, Li Y, et al. Emergence of ceftriaxone⁃resistant Neisseria gonorrhoeae strains harbouring a novel mosaic penA gene in China[J]. J Antimicrob Chemother, 2020,75(4):907⁃910. doi: 10.1093/jac/dkz530. |
[35] | 中国疾病预防控制中心性病控制中心, 中华医学会皮肤性病学分会性病学组, 中国医师协会皮肤科医师分会性病亚专业委员会. 梅毒、淋病和生殖道沙眼衣原体感染诊疗指南(2020年)[J]. 中华皮肤科杂志, 2020,53(3):168⁃179. doi: 10.35541/cjd.20190808. |
[36] | Chen SC, Hu LH, Zhu XY, et al. Gonococcal urethritis caused by a multidrug resistant Neisseria gonorrhoeae strain with high⁃level resistance to spectinomycin in China[J]. Emerg Microbes Infect, 2020,9(1):517⁃519. doi: 10.1080/22221751.2020.1732 836. |
[37] | Chisholm SA, Mouton JW, Lewis DA, et al. Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?[J]. J Antimicrob Chemother, 2010,65(10):2141⁃2148. doi: 10. 1093/jac/dkq289. |
[38] | Unemo M. Current and future antimicrobial treatment of gonorrhoea ⁃ the rapidly evolving Neisseria gonorrhoeae continues to challenge[J]. BMC Infect Dis, 2015,15:364. doi: 10.1186/s12879⁃015⁃1029⁃2. |
[39] | Yin YP, Han Y, Dai XQ, et al. Susceptibility of Neisseria gonorrhoeae to azithromycin and ceftriaxone in China: a retrospective study of national surveillance data from 2013 to 2016[J/OL]. PLoS Med, 2018,15(2):e1002499[2020⁃06⁃24]. https://journals.plos.org/plosmedicine/article?id=10.1371/journal. pmed.1002499. doi: 10.1371/journal. pmed.1002499. |
[1] | 范文葛 张青松 叶迅 魏梅 范志江 张静 王玲 薛峤 陶晓瑜 丁浩 赵军. 男性阴茎附属腺和皮肤淋球菌感染皮损的高频超声研究[J]. 中华皮肤科杂志, 2022, 55(6): 528-531. |
[2] | 陈玉萍 郑海林 张之烽 梅嬛 刘维达 刘沐桑. 南京某医院201株烟曲霉感染患者临床资料与唑类耐药情况回顾性分析[J]. 中华皮肤科杂志, 2022, 55(4): 316-320. |
[3] | 欧敏, 颜韵灵, 郑宝庆, 王晓华. 银屑病与肥胖相关性的研究进展[J]. 中华皮肤科杂志, 2022, 55(2): 181-184. |
[4] | 杨璐 段志敏 李岷. 白念珠菌对棘白菌素类药物耐药机制的研究进展[J]. 中华皮肤科杂志, 2022, 55(12): 1114-1117. |
[5] | 丁甜甜 崔宝红 米淑宏 张杨 郑海林 石继海 刘维达. 浅部与深部感染来源白念珠菌氟康唑耐药株药物敏感性及耐药基因突变比较[J]. 中华皮肤科杂志, 2022, 55(10): 874-878. |
[6] | 蒋佳怡 王大光. 非传染性炎症性甲病的诊疗进展[J]. 中华皮肤科杂志, 2022, 0(1): 20210612-e20210612. |
[7] | 李婷婷 关猛猛 赵娟 康晓静. 单细胞转录组测序在黑素瘤研究中的应用[J]. 中华皮肤科杂志, 2022, 0(1): 20210191-e20210191. |
[8] | 李海洋 林尽染 刘庆梅 倪春雅 吴文育. 微生物群与头皮毛发疾病相关性研究进展[J]. 中华皮肤科杂志, 2022, 0(1): 20201196-e20201196. |
[9] | 卢改会 李涛 刘学伟. 苄星青霉素联合头孢曲松对早期梅毒血清快速血浆反应素环状卡片试验/甲苯胺红不加热血清试验结果影响的Meta分析[J]. 中华皮肤科杂志, 2021, 54(6): 522-526. |
[10] | 邵丽丽 刘全忠. 噬菌体疗法及其在皮肤和泌尿生殖道感染中的应用与展望[J]. 中华皮肤科杂志, 2021, 54(10): 924-927. |
[11] | 杨鑫 郎德休 廖勇 李海涛 彭卓颖 敖俊红 张德全 杨蓉娅. 微进化对阿萨希毛孢子菌生物膜相关表型及耐药性的影响研究[J]. 中华皮肤科杂志, 2021, 54(1): 68-73. |
[12] | 钱革 刘屹球 郭武 刘涛 季江 周武. 78例婴儿疥疮临床特点分析[J]. 中华皮肤科杂志, 2020, 53(9): 715-717. |
[13] | 郎德休 廖勇 杨蓉娅. 痤疮丙酸杆菌的新命名及其与寻常痤疮的相关性[J]. 中华皮肤科杂志, 2020, 53(5): 394-397. |
[14] | 王晓东 哈地丽亚·哈斯木 董潇阳 周珊 刘旭 帕丽达.阿布力孜. 新疆某三甲医院2010—2018年122例头癣患者回顾分析[J]. 中华皮肤科杂志, 2020, 53(4): 290-292. |
[15] | 郑玉梅 吴文海 宋丽雅 何聪芬. 北京31例20 ~ 25岁健康在校女大学生面部主观皮肤类型与皮肤微生物的关系[J]. 中华皮肤科杂志, 2019, 52(7): 467-474. |
|