中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (5): 340-344.doi: 10.35541/cjd.20191198

• 论著 • 上一篇    下一篇

玫瑰痤疮患者阵发性潮红的临床特征分析及对生活质量的影响

施琦    赵志祥    谢红付    李吉    汪犇   

  1. 中南大学湘雅医院皮肤科  国家老年疾病临床医学研究中心，长沙  410008
  • 收稿日期:2019-12-30 修回日期:2020-02-08 发布日期:2020-04-30
  • 通讯作者: 汪犇 E-mail:wangben0804@163.com
  • 基金资助:
    国家自然科学基金（81974480）

Analysis of clinical features of intermittent flushing in patients with rosacea and its impact on quality of life

Shi Qi, Zhao Zhixiang, Xie Hongfu, Li Ji, Wang Ben   

  1. Department of Dermatology, Xiangya Hospital, Central South University, National Clinical Research Center for Geriatric Disorders, Changsha 410008, China
  • Received:2019-12-30 Revised:2020-02-08 Published:2020-04-30
  • Contact: Wang Ben E-mail:wangben0804@163.com
  • Supported by:
    National Natural Science Foundation of China （81974480）

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摘要： 【摘要】 目的 探讨玫瑰痤疮患者阵发性潮红的临床特点及对生活质量的影响。方法 采用前瞻性研究，收集2017年8月至2019年8月湘雅医院皮肤科门诊玫瑰痤疮患者728例，采用阵发性潮红国际标准化量表（FSQ）、持久性红斑医生评分量表（CEA）、患者自评量表（PSA）和视觉模拟评分法（VAS）收集资料，分析阵发性潮红的发作特点、严重程度、对生活的困扰度及其与持久性红斑评分的相关性等。统计分析采用χ2检验和Spearman相关分析。结果 728例患者中，阵发性潮红最常出现的部位为颊部（682例，93.7%）及颧部（617例，84.8%）；持续时间5 min至2 h的患者比例最高（484例，66.5%）；317例（43.6%）受刺激后潮红发作，233例（32.0%）潮红每天发作且1天内多次发作。503例（69.1%）患者潮红的总体评分在中度以上；412例（56.6%）认为潮红可对睡眠造成不同程度的影响，其中59例（8.1%）认为影响可达重度及以上；662例（90.9%）认为潮红对生活有不同程度的影响，其中304例（41.8%）认为影响程度在重度及以上。潮红总体评分和其对生活的困扰评分均与医生评价的持久性红斑严重程度（CEA评分）呈低度正相关（rs = 0.166、0.151，均P＜0.05），与患者自评的红斑严重程度（PSA评分）具有显著相关性（rs = 0.518、0.500，均P＜0.05）。结论 玫瑰痤疮患者的阵发性潮红具有典型的发作部位，发作持续时间较长，频率高，影响患者生活质量，需得到临床医生的重视。

关键词: 红斑痤疮, 生活质量, 阵发性潮红, 临床特征

Abstract: 【Abstract】 Objective To investigate clinical features of intermittent flushing in patients with rosacea, and to evaluate its impact on the quality of life of patients. Methods A prospective study was conducted, a total of 728 patients with rosacea were enrolled from Department of Dermatology, Xiangya Hospital from August 2017 to August 2019. Data were collected by using flushing symptom questionnaire （FSQ）, clinician erythema assessment scale （CEA）, patient′s self-assessment （PSA） and visual analogue scale （VAS）. Clinical features and severity of intermittent flushing episodes, degree of bother and impact on life, and correlation of flushing scores with persistent erythema scores were analyzed. Statistical analysis was carried out by using chi-square test and Spearman correlation analysis. Results Among the 728 patients with rosacea, intermittent flushing most frequently occurred on the cheek （682 cases, 93.7%） and zygomatic region （617 cases, 84.8%）; the proportion of patients with a flushing duration of 5 minutes to 2 hours was the highest （484 cases, 66.5%）; 317 （43.6%） had flushing episodes after stimulation, and 233 （32.0%） had multiple flushing episodes every day. Moreover, 503 patients （69.1%） had an overall flushing score above the moderate level; 412 （56.6%） considered that flushing could affect sleep to varying degrees, of which 59 （8.1%） considered that the impact was severe or very severe; 662 （90.9%） considered that flushing had impact on life to different degrees, of which 304 （41.8%） thought that the impact was severe. Both the overall flushing score and life bother score were positively but lowly correlated with the CEA scores （rs = 0.166, 0.151 respectively, both P < 0.05）, and were positively correlated with the PSA scores （rs = 0.518, 0.500 respectively, both P < 0.05）. Conclusion Intermittent flushing occurs at typical sites of patients with rosacea, with long duration of episodes and high frequency, and affects quality of life of patients, so attention needs to be paid by clinicians.

Key words: Rosacea, Quality of life, Intermittent flushing, Clinical features