Abstract:

We report a case of hydroxyurea-associated multiple verrucous keratoses and squamous cell carcinoma of the skin. A 55-year-old female patient presented with multiple yellowish to brownish verrucous keratotic papules, plaques on both hands and feet, ulcerative mass on left palm. She had a history of bone marrow fibrosis that was well controlled by hydroxyurea therapy for 8 years. Histopathology of ulcerative mass on left palm showed cutaneous squamous cell carcinoma. The patient subsequently underwent left forearm amputation, and the remainder of the lesions were treated by imiquimod.

Key words: Hydroxyurea, Verrucous keratoses, Squamous cell carcinoma, Skin