Abstract: 【Abstract】 Objective To determine classification and clinical features of morphea. Methods A retrospective analysis was conducted on epidemiological information about clinical manifestations of and laboratory data from 180 patients with morphea, who visited Zhongshan Hospital, Fudan University from January 2010 to July 2021. Two-independent-sample t test was used to compare the age at onset between genders, and chi-square test to analyze differences in clinical characteristics between different genders and subtypes. Results Among the 180 patients, 123 were females and 57 were males, with a male-to-female ratio of 1∶2.16. The age at onset of morphea was 28.69 ± 17.97 years for female patients, and 29.90 ± 20.67 years for male patients. Among them, linear morphea was the most common type in this study （68 cases, 37.78%）, followed by plaque morphea （63 cases, 35.00%）, mixed morphea （28 cases, 15.56%） and deep morphea （21 cases, 11.67%）. The disease occurred in all age groups, but the age at onset significantly varied among different clinical subtypes （F = 5.95，P < 0.001）. No significant difference was observed in the age at onset or proportion of clinical subtypes between genders （F = 0.15, P = 0.696; χ2 =2.88, P = 0.410）. Atrophoderma of Pasini and Pierini （APP） was very common （62 cases, 34.44%） in the 180 patients, which mainly manifested as plaques or linear lesions, and 26 out of 45 patients with plaque APP and 11 out of 17 with linear APP were both accompanied by other subtypes of morphea. Among the 75 patients tested for autoantibody profiles, 34 （45.33%） presented with positive results. More diverse types of autoantibodies were found in female patients compared with male patients, and antinuclear antibodies, anti-SSA and anti-SSB antibodies were the most common types. There were various types of comorbidities in female patients, but lichen sclerosus et atrophicus and vitiligo were the most common comorbidities in both genders. Conclusion High incidence and frequent co-occurrence with other subtypes of APP may be the characteristics of Chinese patients with morphea, and it is recommended to classify morphea into plaque, linear, deep and mixed subtypes.

Key words: Scleroderma, localized, Skin manifestations, Classification, Autoantibodies, Atrophoderma of Pasini and Pierini