Abstract: 【Abstract】 A large number of studies have shown that immunoglobulin E （IgE） not only participates in the occurrence and development of allergic reactions, but also induces and aggravates autoimmune reactions through various mechanisms. IgE autoantibodies have been confirmed to be present in a variety of autoimmune skin diseases, and may be involved in the occurrence and development of related diseases by affecting multiple immune cells such as dendritic cells, mast cells, and basophils via binding to autoantigens. This review summarizes the role and possible mechanism of action of IgE in the induction and exacerbation of autoimmune skin diseases such as systemic lupus erythematosus, bullous pemphigoid and chronic idiopathic urticaria, and provides a theoretical basis for clinical diagnosis and treatment.

Key words: Immunoglobulin E, Autoimmune diseases, Lupus erythematosus, systemic, Pemphigoid, bullous, Chronic idiopathic urticaria, IgE autoantibodies