肥大细胞非IgE途径活化新型受体mas相关G蛋白偶联受体X2的研究进展

doi:10.3760/cma.j.issn.0412-4030.2019.02.021

Abstract

Abstract: 【Abstract】 Mast cells （MC）, a major participant in inflammation and allergy, can initiate an early defense response to foreign invaders. Besides expressing high-affinity IgE receptor, MC also expresse a large number of G protein-coupled receptors （GPCRs）. Various studies have shown that cationic micromolecules represented by substance P and many peptidergic drugs can induce MC degranulation through a novel receptor, Mas-related G protein-coupled receptor X2 （MrgprX2）. MrgprX2 plays an important role in allergy, itching and pseudo-allergic drug reactions. It will help explain some clinical difficulties which can not be explained by classical IgE-dependent activation of MC, and provides potential therapeutic targets for MC-mediated diseases.

Key words: Mast cells, Immunoglobulin E, Receptors, G?protein?coupled, Pruritus

Chen Anwei, Bai Xiaoming, Wang Hua. Mas-related G protein-coupled receptor X2: a novel receptor for non-IgE-dependent activation of mast cells[J].Chinese Journal of Dermatology, 2019, 52(2): 142-144.

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Mas-related G protein-coupled receptor X2: a novel receptor for non-IgE-dependent activation of mast cells

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