Abstract: 【Abstract】 Atopic dermatitis （AD） is a common chronic, recurrent, inflammatory, and pruritic skin disease in children. It not only affects sleep quality, growth and development, learning efficiency, social functioning, and mental health, but also significantly reduces the quality of life of affected children and their families, and increases multidimensional medical, social, and economic burdens. In recent years, research into the pathogenesis of AD has advanced substantially, demonstrating that epidermal barrier dysfunction, aberrant type 2 immune responses, microbial dysbiosis, and genetic susceptibility jointly contribute to disease onset and progression. The emergence of biologics and small-molecule targeted therapies has marked the entry of AD treatment into the era of precision medicine, while the concepts in disease management have shifted from “symptom control” to “whole-process management and disease modification”. Meanwhile, progress has been achieved in early prediction and prevention strategies for AD, and “early prevention, precision treatment, and whole-process management” are considered the core principles of effective disease control. This consensus adopts “prediction and prevention-stepwise treatment-comorbidity management-whole-process management” as its core framework, with a focus on key dimensions including tertiary prevention strategies, stratified and individualized treatment approaches, identification and management of common complications and comorbidities, as well as patient education and long-term management. It aims to provide a scientific, standardized, and practical reference for the integrated clinical practice of “prevention-treatment-management” for childhood AD in China, thereby improving prevention and treatment outcomes, enhancing long-term prognosis, improving the quality of life of affected children and their families, and effectively reducing the overall disease burden.

Key words: Dermatitis, atopic, Child, Prevention, Therapy, Management, Consensus