玫瑰痤疮与代谢性疾病相关研究进展

doi:10.35541/cjd.20230523

Abstract

Abstract: 【Abstract】 Rosacea is a common chronic inflammatory skin disorder, and recent studies have shown a close association between rosacea and metabolic diseases. Patients with rosacea often have concomitant conditions such as obesity, dyslipidemia, insulin resistance, and other components of metabolic syndrome, and are also at an increased risk of thyroid dysfunction, hyperuricemia, and other metabolic disorders. This article reviews the research progress on the relationship between rosacea and metabolic syndrome, endocrine-related metabolic diseases, and metabolomics.

Key words: Rosacea, Metabolic diseases, Metabolic syndrome, Insulin resistance, Dyslipidemias, Metabolomics

Xiao Xuejuan, Xie Hongfu, Li Ji, Zhao Zhixiang. Association between rosacea and metabolic diseases[J]. Chinese Journal of Dermatology,2025,e0230523. doi:10.35541/cjd.20230523

References ［38］

［1］	Li J, Wang B, Deng Y, et al. Epidemiological features of rosacea in Changsha, China: a population⁃based, cross⁃sectional study［J］. J Dermatol, 2020,47（5）:497⁃502. doi: 10.1111/1346⁃8138. 15301.
［2］	Deng Z, Chen M, Zhao Z, et al. Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea［J］. Nat Commun, 2023,14（1）:3958. doi: 10.1038/s41467⁃023⁃39761⁃2.
［3］	Akin Belli A, Ozbas Gok S, Akbaba G, et al. The relationship between rosacea and insulin resistance and metabolic syndrome［J］. Eur J Dermatol, 2016,26（3）:260⁃264. doi: 10.1684/ejd. 2016.2748.
［4］	Akin Belli A, Alatas ET, Kara Polat A, et al. Assessment of thyroid disorders in patients with rosacea: a large case⁃control study［J］. An Bras Dermatol, 2021,96（5）:539⁃543. doi: 10.1016/j.abd.2021.02.004.
［5］	Nam JH, Yang J, Park J, et al. Association between rosacea severity and relative muscle mass: a cross⁃sectional study［J］. J Dermatol, 2019,46（1）:11⁃17. doi: 10.1111/1346⁃8138.14689.
［6］	Chen Q, Shi X, Tang Y, et al. Association between rosacea and cardiometabolic disease: a systematic review and meta⁃analysis［J］. J Am Acad Dermatol, 2020,83（5）:1331⁃1340. doi: 10.1016/j.jaad.2020.04.113.
［7］	Li S, Cho E, Drucker AM, et al. Obesity and risk for incident rosacea in US women［J］. J Am Acad Dermatol, 2017,77（6）:1083⁃1087.e5. doi: 10.1016/j.jaad.2017.08.032.
［8］	Huang PL. A comprehensive definition for metabolic syndrome［J］. Dis Model Mech, 2009,2（5⁃6）:231⁃237. doi: 10.1242/dmm. 001180.
［9］	Jiang CQ, Xu L, Zhang WS, et al. Adiposity and mortality in older Chinese: an 11⁃year follow⁃up of the Guangzhou Biobank Cohort Study［J］. Sci Rep, 2020,10（1）:1924. doi: 10.1038/s41598⁃020⁃58633⁃z.
［10］	应洁雅, 相文忠, 宋秀祖. 代谢综合征与皮肤病［J］. 中华皮肤科杂志, 2021,54（7）:642⁃645. doi: 10.35541/cjd.20191018.
［11］	Su X, Chen X, Wang B. Pathology of metabolically⁃related dyslipidemia［J］. Clin Chim Acta, 2021,521:107⁃115. doi: 10. 1016/j.cca.2021.06.029.
［12］	Su X, Cheng Y, Chang D. Lipid⁃lowering therapy: guidelines to precision medicine［J］. Clin Chim Acta, 2021,514:66⁃73. doi: 10.1016/j.cca.2020.12.019.
［13］	Berberich AJ, Hegele RA. A modern approach to dyslipidemia［J］. Endocr Rev, 2022,43（4）:611⁃653. doi: 10.1210/endrev/bnab037.
［14］	Duman N, Ersoy Evans S, Atakan N. Rosacea and cardiovascular risk factors: a case control study［J］. J Eur Acad Dermatol Venereol, 2014,28（9）:1165⁃1169. doi: 10.1111/jdv.12234.
［15］	Haber R, El Gemayel M. Comorbidities in rosacea: a systematic review and update［J］. J Am Acad Dermatol, 2018,78（4）:786⁃792.e8. doi: 10.1016/j.jaad.2017.09.016.
［16］	Spoendlin J, Voegel JJ, Jick SS, et al. A study on the epidemiology of rosacea in the U.K［J］. Br J Dermatol, 2012,167（3）:598⁃605. doi: 10.1111/j.1365⁃2133.2012.11037.x.
［17］	Reszke R, Pełka D, Walasek A, et al. Skin disorders in elderly subjects［J］. Int J Dermatol, 2015,54（9）:e332⁃e338. doi: 10.1111/ijd.12832.
［18］	Aldrich N, Gerstenblith M, Fu P, et al. Genetic vs environmental factors that correlate with rosacea: a cohort⁃based survey of twins［J］. JAMA Dermatol, 2015,151（11）:1213⁃1219. doi: 10.1001/jamadermatol.2015.2230.
［19］	Demir S, Nawroth PP, Herzig S, et al. Emerging targets in type 2 diabetes and diabetic complications［J］. Adv Sci （Weinh）, 2021,8（18）:e2100275. doi: 10.1002/advs.202100275.
［20］	Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance［J］. Nature, 2006,440（7086）:944⁃948. doi: 10.1038/nature04634.
［21］	Spoendlin J, Voegel JJ, Jick SS, et al. Risk of rosacea in patients with diabetes using insulin or oral antidiabetic drugs［J］. J Invest Dermatol, 2013,133（12）:2790⁃2793. doi: 10.1038/jid.2013.225.
［22］	Li Y, Guo L, Hao D, et al. Association between rosacea and cardiovascular diseases and related risk factors: a systematic review and meta⁃analysis［J］. Biomed Res Int, 2020,2020:7015249. doi: 10.1155/2020/7015249.
［23］	Li Y, Yang L, Wang Y, et al. Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation［J］. Pharmacol Res, 2021,174:105971. doi: 10.1016/j.phrs.2021.105971.
［24］	Li WQ, Zhang M, Danby FW, et al. Personal history of rosacea and risk of incident cancer among women in the US［J］. Br J Cancer, 2015,113（3）:520⁃523. doi: 10.1038/bjc.2015.217.
［25］	Egeberg A, Fowler JF Jr, Gislason GH, et al. Rosacea and risk of cancer in Denmark［J］. Cancer Epidemiol, 2017,47:76⁃80. doi: 10.1016/j.canep.2017.01.006.
［26］	Izikson L, English JC 3rd, Zirwas MJ. The flushing patient: differential diagnosis, workup, and treatment［J］. J Am Acad Dermatol, 2006,55（2）:193⁃208. doi: 10.1016/j.jaad.2005.07.057.
［27］	İkizoğlu G. Red face revisited: flushing［J］. Clin Dermatol, 2014,32（6）:800⁃808. doi: 10.1016/j.clindermatol.2014.02.019.
［28］	Demiray A, Afsar B, Covic A, et al. The role of uric acid in the acute myocardial infarction: a narrative review［J］. Angiology, 2022,73（1）:9⁃17. doi: 10.1177/00033197211012546.
［29］	Karaosmanoglu N, Karaaslan E, Ozdemir Cetinkaya P. Evaluation of serum uric acid levels in patients with rosacea［J］. Arch Dermatol Res, 2020,312（6）:447⁃451. doi: 10.1007/s00403⁃020⁃02033⁃w.
［30］	Bechstein SK, Ochsendorf F. Acne and rosacea in pregnancy［J］. Hautarzt, 2017,68（2）:111⁃119. doi: 10.1007/s00105⁃016⁃3918⁃8.
［31］	Wu WH, Geng H, Cho E, et al. Reproductive and hormonal factors and risk of incident rosacea among US White women［J］. J Am Acad Dermatol, 2022,87（1）:138⁃140. doi: 10.1016/j.jaad.2021.06.865.
［32］	Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation［J］. Physiol Rev, 2009,89（1）:147⁃191. doi: 10.1152/physrev.00010.2008.
［33］	Schaap FG, Trauner M, Jansen PL. Bile acid receptors as targets for drug development［J］. Nat Rev Gastroenterol Hepatol, 2014,11（1）:55⁃67. doi: 10.1038/nrgastro.2013.151.
［34］	Fan M, Wang Y, Jin L, et al. Bile acid⁃mediated activation of brown fat protects from alcohol⁃induced steatosis and liver injury in mice［J］. Cell Mol Gastroenterol Hepatol, 2022,13（3）:809⁃826. doi: 10.1016/j.jcmgh.2021.12.001.
［35］	Xiao W, Chen M, Peng Q, et al. Lithocholic acid promotes rosacea⁃like skin inflammation via G protein⁃coupled bile acid receptor 1［J］. Biochim Biophys Acta Mol Basis Dis, 2022,1868（12）:166563. doi: 10.1016/j.bbadis.2022.166563.
［36］	Liu T, Xiao W, Chen M, et al. Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea［J］. JCI Insight, 2022,7（22）:e161870. doi: 10.1172/jci.insight.161870.
［37］	Ekiz O, Balta I, Sen BB, et al. Vitamin D status in patients with rosacea［J］. Cutan Ocul Toxicol, 2014,33（1）:60⁃62. doi: 10. 3109/15569527.2013.797907.
［38］	Akdogan N, Alli N, Incel Uysal P, et al. Role of serum 25⁃hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case⁃control study［J］. Clin Exp Dermatol, 2019,44（4）:397⁃403. doi: 10.1111/ced. 13769.

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Association between rosacea and metabolic diseases

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