Chinese Journal of Dermatology ›› 2024, e20220366.doi: 10.35541/cjd.20220366

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Research progress in atopic diseases from the perspective of metabolomics

Chen Zhu1, Dong Liping1, Xiao Fengli1,2   

  1. 1Department of Dermatology and Venereology, the First Affiliated Hospital, Institute of Dermatology, Anhui Medical University, Anhui 230032, China; 2The Center for Scientific Research, Anhui Medical University, Anhui 230032, China
  • Received:2022-05-23 Revised:2023-08-03 Online:2024-01-29 Published:2024-01-30
  • Contact: Xiao Fengli
  • Supported by:
    National Natural Science Foundation of China(81972926)

Abstract: 【Abstract】 Atopic diseases are a series of allergic diseases, including atopic dermatitis, allergic asthma, and allergic rhinitis, etc., with complex pathogenesis. Metabolomics studies focus on endogenous small-molecule compounds at the end of different metabolic pathways, which can directly reflect the human body′s functional state. In recent years, a large number of metabolomic studies have shown various abnormal biochemical metabolic pathways in patients with atopic diseases, specifically manifesting as aberrantly high levels of some amino acids, unsaturated fatty acids, and microbial metabolites. This review summarizes the progress in metabolomics research on atopic diseases in recent years, to further reveal the potential pathogenesis of atopic diseases.

Key words: Dermatitis, atopic, Rhinitis, allergic, Asthma, Metabolomics, Biomarkers, Differential metabolites, Phenotype