Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (9): 892-895.doi: 10.35541/cjd.20210252

• Reviews • Previous Articles    

Clinical phenotypes and genotypes of hidradenitis suppurativa/acne inversa

Wang Wenzhu1, Wang Baoxi2, He Yanyan1, Xu Haoxiang1   

  1. 1Department of Dermatology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 2Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
  • Received:2021-03-26 Revised:2021-10-12 Online:2023-09-15 Published:2023-09-07
  • Contact: He Yanyan;Xu Haoxiang;
  • Supported by:
    National Natural Science Foundation of China (82073471, 81703148, 81673087, 81472905); CAMS Innovation Fund for Medical Sciences (2016-I2M-1-003)

Abstract: 【Abstract】 Hidradenitis suppurativa(HS)/acne inversa(AI) is a chronic, recurrent and inflammatory skin disease caused by follicular atresia with varying clinical manifestations, and there is no unified classification criteria for it in China and other countries. Based on its clinical characteristics, gene mutations and their correlations, researchers have enriched the subtype classification of HS/AI. This review summarizes recent advances in clinical phenotypes and genotypes of HS/AI as well as their relationships, in order to help clinicians better understand the disease, and provide a theoretical basis for correct diagnosis and individualized treatment strategies.

Key words: Hidradenitis suppurativa, Phenotype, Genotype, Genotype-phenotype correlation, Acne inversa