Chinese Journal of Dermatology ›› 2021, Vol. 54 ›› Issue (4): 318-324.doi: 10.35541/cjd.20201144
• Original Articles • Previous Articles Next Articles
Li Wenrui1, Zhang Yuanyuan1, Jia Weixue1, He Yanyan1,2, Xu Haoxiang1,2, Lin Lin1, Li Chengrang1,2
Received:
2020-11-29
Revised:
2021-01-19
Online:
2021-04-15
Published:
2021-03-31
Contact:
Lin Lin; Li Chengrang
E-mail:dllon3@163.com; nylcr72@163.com
Supported by:
Li Wenrui, Zhang Yuanyuan, Jia Weixue, He Yanyan, Xu Haoxiang, Lin Lin, Li Chengrang, . Effect of PSENEN gene silencing on the proliferation of and γ-secretase expression in HaCaT cells[J]. Chinese Journal of Dermatology, 2021, 54(4): 318-324.doi:10.35541/cjd.20201144
[1] | Wang B, Yang W, Wen W, et al. Gamma⁃secretase gene mutations in familial acne inversa[J]. Science, 2010,330(6007):1065. doi: 10.1126/science.1196284. |
[2] | 毛秋霞, 张婉璐, 何艳艳, 等. 慢病毒介导shRNA沉默Nicastrin基因的人永生化角质形成细胞模型构建[J]. 中华皮肤科杂志, 2017,50(4):268⁃272. doi: 10.3760/cma.j.issn.0412⁃4030.2017.04.008. |
[3] | Zhou C, Wen GD, Soe LM, et al. Novel mutations in PSENEN gene in two Chinese acne inversa families manifested as familial multiple comedones and Dowling⁃Degos disease[J]. Chin Med J (Engl), 2016,129(23):2834⁃2839. doi: 10.4103/0366⁃6999.194 648. |
[4] | Li C, Li W, Xu H, et al. PSENEN mutation carriers with co⁃manifestation of acne inversa (AI) and Dowling⁃Degos disease (DDD): is AI or DDD the subphenotype?[J]. J Invest Dermatol, 2017,137(10):2234⁃2236. doi: 10.1016/j.jid.2017.05.021. |
[5] | von Laffert M, Stadie V, Wohlrab J, et al. Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae[J]. Br J Dermatol, 2011,164(2):367⁃371. doi: 10.1111/j.1365⁃2133.2010.10034.x. |
[6] | Pink AE, Dafou D, Desai N, et al. Hidradenitis suppurativa: haploinsufficiency of gamma⁃secretase components does not affect gamma⁃secretase enzyme activity in vitro[J]. Br J Dermatol, 2016,175(3):632⁃635. doi: 10.1111/bjd.14621. |
[7] | Xiao X, He Y, Li C, et al. Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3⁃kinase/AKT signalling pathways[J]. Br J Dermatol, 2016,174(3):522⁃532. doi: 10.1111/bjd.14223. |
[8] | Pavlovsky M, Sarig O, Eskin⁃Schwartz M, et al. A phenotype combining hidradenitis suppurativa with Dowling⁃Degos disease caused by a founder mutation in PSENEN[J]. Br J Dermatol, 2018,178(2):502⁃508. doi: 10.1111/bjd.16000. |
[9] | He Y, Xu H, Li C, et al. Nicastrin/miR⁃30a⁃3p/RAB31 axis regulates keratinocyte differentiation by impairing EGFR signaling in familial acne inversa[J]. J Invest Dermatol, 2019,139(1):124⁃134. doi: 10.1016/j.jid.2018.07.020. |
[10] | Vekic DA, Frew J, Cains GD. Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1[J]. Australas J Dermatol, 2018,59(4):267⁃277. doi: 10.1111/ajd.12 770. |
[11] | Nazary M, van der Zee HH, Prens EP, et al. Pathogenesis and pharmacotherapy of Hidradenitis suppurativa[J]. Eur J Pharmacol, 2011,672(1⁃3):1⁃8. doi: 10.1016/j.ejphar.2011.08. 047. |
[12] | Nomura T. Hidradenitis suppurativa as a potential subtype of autoinflammatory keratinization disease[J]. Front Immunol, 2020,11:847. doi: 10.3389/fimmu.2020.00847. |
[13] | Ralser DJ, Basmanav FB, Tafazzoli A, et al. Mutations in γ⁃secretase subunit⁃encoding PSENEN underlie Dowling⁃Degos disease associated with acne inversa[J]. J Clin Invest, 2017,127(4):1485⁃1490. doi: 10.1172/JCI90667. |
[14] | Garcovich S, Tricarico PM, Nait⁃Meddour C, et al. Novel nicastrin mutation in hidradenitis suppurativa⁃Dowling⁃Degos disease clinical phenotype: more than just clinical overlap?[J]. Br J Dermatol, 2020,183(4):758⁃759. doi: 10.1111/bjd.19121. |
[15] | 张婉璐, 张媛媛, 吴英达, 等. NCSTN基因沉默对HaCaT细胞增殖分化的影响[J]. 中华皮肤科杂志, 2020,53(9):704⁃709. doi: 10.35541/cjd.20191077. |
[16] | Cai T, Tomita T. Structure⁃activity relationship of presenilin in γ⁃secretase⁃mediated intramembrane cleavage[J]. Semin Cell Dev Biol, 2020,105:102⁃109. doi: 10.1016/j.semcdb.2020.02.006. |
[17] | Dries DR, Yu G. Assembly, maturation, and trafficking of the gamma⁃secretase complex in Alzheimer′s disease[J]. Curr Alzheimer Res, 2008,5(2):132⁃146. doi: 10.2174/15672050878 3954695. |
[18] | Escamilla⁃Ayala A, Wouters R, Sannerud R, et al. Contribution of the presenilins in the cell biology, structure and function of γ⁃secretase[J]. Semin Cell Dev Biol, 2020,105:12⁃26. doi: 10. 1016/j.semcdb.2020.02.005. |
[19] | Carroll CM, Li YM. Physiological and pathological roles of the γ⁃secretase complex[J]. Brain Res Bull, 2016,126(Pt 2):199⁃206. doi: 10.1016/j.brainresbull.2016.04.019. |
[20] | McGrath JA. Concurrent hidradenitis suppurativa and Dowling⁃Degos disease taken down a ′Notch′[J]. Br J Dermatol, 2018,178(2):328. doi: 10.1111/bjd.16068. |
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