细胞铁死亡参与白癜风发病机制与相关治疗药物研究进展

doi:10.35541/cjd.20240095

Abstract

Abstract: 【Abstract】 Melanocyte death is the most notable feature of vitiligo, and ferroptosis is a unique pattern of programmed cell death, characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species. Recent studies have found that ferroptosis is involved in the damage to melanocytes in the development of vitiligo. This review summarizes the possible mechanisms of ferroptosis in vitiligo and related therapeutic agents, aiming to provide novel insights into the pathogenesis of vitiligo, potential therapeutic targets, and associated targeted therapies.

Key words: Vitiligo, Ferroptosis, Reactive oxygen species, Lipid peroxidation, Oxidative stress, Drugs

Xu Xuqing, Hu Wen, Kang Xiaojing. Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents[J]. Chinese Journal of Dermatology, 2025, 58(9): 886-889.doi:10.35541/cjd.20240095

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Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents

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