纳米医学在恶性黑色素瘤中的诊断和治疗新策略

doi:10.35541/cjd.20230109

Abstract

Abstract: 【Abstract】 Melanoma is the most aggressive skin cancers, and its diagnosis and treatment remain a formidable challenge. At present, treatment methods for advanced melanoma include immunotherapy, chemotherapy, molecular targeted therapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, etc., but their efficacy is limited. Application of emerging nanomaterials in the diagnosis and treatment of cancers can improve the drug bioavailability and cancer cell-targeted precision. This review summarizes the latest research progress on some nanoparticles used for the diagnosis and different treatments of melanoma.

Key words: Melanoma, Nanomedicine, Liposomes, Magnetite nanoparticles, Diagnosis, Therapy

Yan Kexin, Xu Xiulian. Nanomedicine: a new strategy for the diagnosis and treatment of melanoma[J]. Chinese Journal of Dermatology,2024,e20230109. doi:10.35541/cjd.20230109

References ［46］

［1］	Yang K, Oak A, Slominski RM, et al. Current molecular markers of melanoma and treatment targets［J］. Int J Mol Sci, 2020,21（10）:3535. doi: 10.3390/ijms21103535.
［2］	Al⁃Zoubi MS, Al⁃Zoubi RM. Nanomedicine tactics in cancer treatment: challenge and hope［J］. Crit Rev Oncol Hematol, 2022,174:103677. doi: 10.1016/j.critrevonc.2022.103677.
［3］	Peng S, Xiao F, Chen M, et al. Tumor⁃microenvironment⁃responsive nanomedicine for enhanced cancer immunotherapy［J］. Adv Sci （Weinh）, 2022,9（1）:e2103836. doi: 10.1002/advs. 202103836.
［4］	Farjadian F, Ghasemi A, Gohari O, et al. Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities［J］. Nanomedicine （Lond）, 2019,14（1）:93⁃126. doi: 10.2217/nnm⁃2018⁃0120.
［5］	Wang P, Yang W, Shen S, et al. Differential diagnosis and precision therapy of two typical malignant cutaneous tumors leveraging their tumor microenvironment: a photomedicine strategy［J］. ACS Nano, 2019,13（10）:11168⁃11180. doi: 10.1021/ acsnano.9b04070.
［6］	Portilho FL, Helal⁃Neto E, Cabezas SS, et al. Magnetic core mesoporous silica nanoparticles doped with dacarbazine and labelled with 99mTc for early and differential detection of metastatic melanoma by single photon emission computed tomography［J］. Artif Cells Nanomed Biotechnol, 2018,46（sup1）:1080⁃1087. doi: 10.1080/21691401.2018.1443941.
［7］	Zou Y, Wei Y, Sun Y, et al. Cyclic RGD⁃functionalized and disulfide⁃crosslinked iodine⁃rich polymersomes as a robust and smart theranostic agent for targeted CT imaging and chemotherapy of tumor［J］. Theranostics, 2019,9（26）:8061⁃8072. doi: 10.7150/thno.37184.
［8］	Qiu X, Wu X, Fang X, et al. Raman spectroscopy combined with deep learning for rapid detection of melanoma at the single cell level［J］. Spectrochim Acta A Mol Biomol Spectrosc, 2023,286:122029. doi: 10.1016/j.saa.2022.122029.
［9］	Zhang Y, Takahashi Y, Hong SP, et al. High⁃resolution label⁃free 3D mapping of extracellular pH of single living cells［J］. Nat Commun, 2019,10（1）:5610. doi: 10.1038/s41467⁃019⁃13535⁃1.
［10］	Ou YC, Wen X, Johnson CA, et al. Multimodal multiplexed immunoimaging with nanostars to detect multiple immuno⁃markers and monitor response to immunotherapies［J］. ACS Nano, 2020,14（1）:651⁃663. doi: 10.1021/acsnano.9b07326.
［11］	Jenkins RW, Fisher DE. Treatment of advanced melanoma in 2020 and beyond［J］. J Invest Dermatol, 2021,141（1）:23⁃31. doi: 10.1016/j.jid.2020.03.943.
［12］	Carlino MS, Larkin J, Long GV. Immune checkpoint inhibitors in melanoma［J］. Lancet, 2021,398（10304）:1002⁃1014. doi: 10. 1016/S0140⁃6736（21）01206⁃X.
［13］	Yang X, Fan J, Wu Y, et al. Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy［J］. Nanomedicine, 2021,37:102443. doi: 10.1016/j.nano.2021.102443.
［14］	Hu M, Zhang J, Kong L, et al. Immunogenic hybrid nanovesicles of liposomes and tumor⁃derived nanovesicles for cancer immunochemotherapy［J］. ACS Nano, 2021,15（2）:3123⁃3138. doi: 10.1021/acsnano.0c09681.
［15］	Salotto KE, Olson WC Jr, Pollack KE, et al. A nano⁃enhanced vaccine for metastatic melanoma immunotherapy［J］. Cancer Drug Resist, 2022,5（3）:829⁃845. doi: 10.20517/cdr.2021.132.
［16］	Sun Y, Lu D, Yin Y, et al. PTENα functions as an immune suppressor and promotes immune resistance in PTEN⁃mutant cancer［J］. Nat Commun, 2021,12（1）:5147. doi: 10.1038/s41467⁃021⁃25417⁃6.
［17］	Lin YX, Wang Y, Ding J, et al. Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models［J］. Sci Transl Med, 2021,13（599）:eaba9772. doi: 10.1126/scitranslmed.aba9772.
［18］	Christofides A, Strauss L, Yeo A, et al. The complex role of tumor⁃infiltrating macrophages［J］. Nat Immunol, 2022,23（8）:1148⁃1156. doi: 10.1038/s41590⁃022⁃01267⁃2.
［19］	Rao L, Zhao SK, Wen C, et al. Activating macrophage⁃mediated cancer immunotherapy by genetically edited nanoparticles［J］. Adv Mater, 2020,32（47）:e2004853. doi: 10.1002/adma.202004853.
［20］	Guo W, Wang H, Li C. Signal pathways of melanoma and targeted therapy［J］. Signal Transduct Target Ther, 2021,6（1）:424. doi: 10.1038/s41392⁃021⁃00827⁃6.
［21］	Epshtein Y, Blau R, Pisarevsky E, et al. Polyglutamate⁃based nanoconjugates for image⁃guided surgery and post⁃operative melanoma metastases prevention［J］. Theranostics, 2022,12（14）:6339⁃6362. doi: 10.7150/thno.72941.
［22］	Zhang MJ, Liang MY, Yang SC, et al. Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis［J］. Chem Commun （Camb）, 2023,59（7）:932⁃935. doi: 10.1039/d2cc05498a.
［23］	Pisarevsky E, Blau R, Epshtein Y, et al. Rational design of polyglutamic acid delivering an optimized combination of drugs targeting mutated BRAF and MEK in melanoma［J］. Adv Ther （Weinh）, 2020,3（8）:2000028 ［pii］. doi: 10.1002/adtp.202000028.
［24］	Shinkuma S. Advances in gene therapy and their application to skin diseases: a review［J］. J Dermatol Sci, 2021,103（1）:2⁃9. doi: 10.1016/j.jdermsci.2021.05.004.
［25］	Liu J, Yang L, Yuan X, et al. Targeted nanotherapeutics using LACTB gene therapy against melanoma［J］. Int J Nanomedicine, 2021,16:7697⁃7709. doi: 10.2147/IJN.S331519.
［26］	Ma Y, Lin H, Wang P, et al. A miRNA⁃based gene therapy nanodrug synergistically enhances pro⁃inflammatory antitumor immunity against melanoma［J］. Acta Biomater, 2023,155:538⁃553. doi: 10.1016/j.actbio.2022.11.016.
［27］	Zhang X, Cai A, Gao Y, et al. Treatment of melanoma by nano⁃conjugate⁃delivered wee1 siRNA［J］. Mol Pharm, 2021,18（9）:3387⁃3400. doi: 10.1021/acs.molpharmaceut.1c00316.
［28］	Zhang Z, Xu D, Wang J, et al. Rolling circle amplification⁃based dna nano⁃assembly for targeted drug delivery and gene therapy［J］. Biomacromolecules, 2023,24（1）:439⁃448. doi: 10.1021/acs. biomac.2c01271.
［29］	Zahraie N, Perota G, Dehdari Vais R, et al. Simultaneous chemotherapy/sonodynamic therapy of the melanoma cancer cells using a gold⁃paclitaxel nanostructure［J］. Photodiagnosis Photodyn Ther, 2022,39:102991. doi: 10.1016/j.pdpdt.2022. 102991.
［30］	Bhattarai RS, Bariwal J, Kumar V, et al. pH⁃sensitive nanomedicine of novel tubulin polymerization inhibitor for lung metastatic melanoma［J］. J Control Release, 2022,350:569⁃583. doi: 10.1016/j.jconrel.2022.08.023.
［31］	Li A, Zhao J, Fu J, et al. Recent advances of biomimetic nano⁃systems in the diagnosis and treatment of tumor［J］. Asian J Pharm Sci, 2021,16（2）:161⁃174. doi: 10.1016/j.ajps.2019.08. 001.
［32］	Molinaro R, Martinez JO, Zinger A, et al. Leukocyte⁃mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma［J］. Biomater Sci, 2020,8（1）:333⁃341. doi: 10.1039/c9bm01766f.
［33］	Wu M, Mei T, Lin C, et al. Melanoma cell membrane biomimetic versatile cus nanoprobes for homologous targeting photoacoustic imaging and photothermal chemotherapy［J］. ACS Appl Mater Interfaces, 2020,12（14）:16031⁃16039. doi: 10.1021/acsami. 9b23177.
［34］	Naidoo C, Kruger CA, Abrahamse H. Photodynamic therapy for metastatic melanoma treatment: a review［J］. Technol Cancer Res Treat, 2018,17:15330338 18791795. doi: 10.1177/1533033 818791795.
［35］	Huang X, Mu N, Ding Y, et al. Targeted delivery and enhanced uptake of chemo⁃photodynamic nanomedicine for melanoma treatment［J］. Acta Biomater, 2022,147:356⁃365. doi: 10.1016/j.actbio.2022.05.015.
［36］	Bian Q, Huang L, Xu Y, et al. A facile low⁃dose photosensitizer⁃incorporated dissolving microneedles⁃based composite system for eliciting antitumor immunity and the abscopal effect［J］. ACS Nano, 2021,15（12）:19468⁃19479. doi: 10.1021/acsnano. 1c06225.
［37］	Wang Y, Zhao Z, Liu C, et al. B16 membrane⁃coated vesicles for combined photodynamic therapy and immunotherapy shift immune microenvironment of melanoma［J］. Int J Nanomedicine, 2022,17:855⁃868. doi: 10.2147/IJN.S338488.
［38］	Hou X, Tao Y, Li X, et al. CD44⁃targeting oxygen self⁃sufficient nanoparticles for enhanced photodynamic therapy against malignant melanoma［J］. Int J Nanomedicine, 2020,15:10401⁃10416. doi: 10.2147/IJN.S283515.
［39］	Zhao L, Zhang X, Wang X, et al. Recent advances in selective photothermal therapy of tumor［J］. J Nanobiotechnology, 2021,19（1）:335. doi: 10.1186/s12951⁃021⁃01080⁃3.
［40］	S M, E S, R DV, et al. Phototherapy and sonotherapy of melanoma cancer cells using nanoparticles of selenium⁃polyethylene glycol⁃curcumin as a dual⁃mode sensitizer［J］. J Biomed Phys Eng, 2020,10（5）:597⁃606. doi: 10.31661/jbpe.v0i0.1912⁃1039.
［41］	Soratijahromi E, Mohammadi S, Dehdari Vais R, et al. Photothermal/sonodynamic therapy of melanoma tumor by a gold/manganese dioxide nanocomposite: in vitro and in vivo studies［J］. Photodiagnosis Photodyn Ther, 2020,31:101846. doi: 10. 1016/j.pdpdt.2020.101846.
［42］	Wang S, Ma Z, Shi Z, et al. Chidamide stacked in magnetic polypyrrole nano⁃composites counter thermotolerance and metastasis for visualized cancer photothermal therapy［J］. Drug Deliv, 2022,29（1）:1312⁃1325. doi: 10.1080/10717544.2022. 2068697.
［43］	Heshmati Aghda N, Torres Hurtado S, Abdulsahib SM, et al. Dual photothermal/chemotherapy of melanoma cells with albumin nanoparticles carrying indocyanine green and doxorubicin leads to immunogenic cell death［J］. Macromol Biosci, 2022,22（2）:e2100353. doi: 10.1002/mabi.202100353.
［44］	Baskar R, Lee KA, Yeo R, et al. Cancer and radiation therapy: current advances and future directions［J］. Int J Med Sci, 2012,9（3）:193⁃199. doi: 10.7150/ijms.3635.
［45］	Chen MH, Lee CH, Liang HK, et al. Integrating the microneedles with carboplatin to facilitate the therapeutic effect of radiotherapy for skin cancers［J］. Biomater Adv, 2022,141:213113. doi: 10.1016/j.bioadv.2022.213113.
［46］	Chan L, Gao P, Zhou W, et al. Sequentially triggered delivery system of black phosphorus quantum dots with surface charge⁃switching ability for precise tumor radiosensitization［J］. ACS Nano, 2018,12（12）:12401⁃12415. doi: 10.1021/acsnano.8b06483.

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Nanomedicine: a new strategy for the diagnosis and treatment of melanoma

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