Abstract: 【Abstract】 Traditionally, it is believed that atopic dermatitis （AD） usually starts in infancy or childhood. However, adult-onset AD （adult-onset AD） occurring at the age of ≥ 18 years is not uncommon, but has not received due attention. There are overlaps and differences between adult-onset AD and childhood-onset AD in terms of genetic factors, triggers, pathogenesis, clinical manifestations, etc. It is undoubtedly of great practical significance to understand and accept the concept of adult-onset AD in clinical practice. However, there are many problems to be solved, especially the establishment of special diagnostic criteria and management models of adult-onset AD.

Key words: Dermatitis, atopic, Epidemiology, Skin manifestations, Genetics, medical, Adult-onset atopic dermatitis