Abstract: Huang Lei, Liu Aimin, Dai Yuwei, Fu Haidong, Wang Jingjing, Mao Jianhua. Department of Nephrology, Children′s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Corresponding author: Liu Aimin, Email: lamhz@163.com 【Abstract】 Objective To investigate the clinical characteristics of childhood anaphylactoid purpura. Methods Seven hundred and sixty children with anaphylactoid purpura were included in this retrospective study. The clinicopathological features of childhood anaphylactoid purpura were analyzed, including age at onset, gender, season at onset, clinical and pathological manifestations, and complications such as purpura nephritis. Results Childhood anaphylactoid purpura commonly affected preschool and school-age children, and usually occurred in winter or spring. Of these patients, 265 （34.87%） had gastrointestinal symptoms, 298 （39.21%） had joint involvement, and 223 （29.34%） had renal impairment. Purpura nephritis mainly manifested as haematuria, proteinuria and nephritic syndrome, and was diagnosed in 91.91% （91） of the patients receiving renal biopsy. The pathological grade of purpura nephritis varied from Ⅱ to Ⅲ in these patients. The distribution pattern of purpura was associated with complications. Conclusions Anaphylactoid purpura has age and season predilection. Purpura in both lower and upper extremities is likely to be complicated by gastrointestinal haemorrhage and joint involvement, and lower extremity purpura is more frequently to be complicated by nephritis than purpura in both lower and upper extremities. In general, childhood anaphylactoid purpura is a mild condition with a good prognosis.

Key words: Purpura, Schoenlein-Henoch, Critical pathways, Child