Abstract: 【Abstract】 Objective To explore the role of systematic wound management in the treatment of Stevens-Johnson syndrome （SJS）/toxic epidermal necrolysis （TEN） in children. Methods Clinical data were collected from 5 children with SJS/TEN, who were admitted to the Department of Dermatology, Tianjin Children′s Hospital from October 2019 to August 2021, and retrospectively analyzed to investigate the role of systematic management of the skin and mucosa wound besides drug therapy in the treatment of SJS/TEN. Results The 5 patients, including 1 case of SJS, 1 case of SJS/TEN overlap syndrome, and 3 cases of TEN, were aged 2 to 13 years, and were cured and discharged after the treatment with intravenous methylprednisolone and systematic wound management. Among the 5 children, the severity of TEN scores （STENS） were 18.6 ± 1.9 points at admission, and 13.8 ± 1.9, 4.4 ± 0.5, and 2.0 ± 0.7 points on days 7, 10, and 14 during hospitalization, respectively; the time to complete re-epithelialization was 10 ± 2.1 days, and the length of hospital stay was 14.4 ± 4.16 days. During 4-month multidisciplinary follow-up, no scars or complications of the eyes, mouth, genitalia, or lungs occurred. Conclusion Systematic wound management is helpful to control the progress of SJS/TEN, accelerate wound healing, and improve patients′ quality of life.

Key words: Child, Stevens-Johnson syndrome, Wound management, Treatment