Abstract: 【Abstract】 Generalized pustular psoriasis （GPP） is a severe autoinflammatory skin disease characterized clinically by sterile pustules on a background of diffuse erythema, with a prolonged disease course and a high risk of mortality. In recent years, variants in genes such as IL36RN, CARD14, and AP1S3 have been confirmed to be closely associated with GPP, and their pathogenic mechanisms mainly involve multiple inflammatory pathways, particularly the interleukin-36 cytokine axis. In addition, associations between GPP and several other genes, including MPO, SERPINA1, SERPINA3, BTN3A3, TNIP1, TGFBR2, and MEFV, have also been gradually identified, further expanding the current understanding of the genetic basis of GPP. This article reviews susceptibility genes associated with GPP and their pathogenic mechanisms, aiming to provide a theoretical basis and potential targets for early diagnosis, targeted therapy, and prognostic evaluation of this disease.

Key words: Psoriasis, Mutation, Genetic variation, Susceptibility genes, Generalized pustular psoriasis, Pathogenesis