干细胞在头皮衰老中的作用及相关治疗策略

doi:10.35541/cjd.20240619

Abstract

Abstract: 【Abstract】 Changes in hair follicle stem cells （HFSCs） can affect scalp aging and hair growth. With increasing age, HFSCs exhibit a decrease in quiescence maintenance and self-renewal capacity, as well as differentiation potential, leading to shortened hair growth cycles and even hair loss. This review summarizes recent research advances in the multifactorial interactions underlying hair loss, including the regulatory mechanisms of HFSC quiescence, the impact of aging on HFSC function, and aging of the stem cell microenvironment. Additionally, this review discusses the relationship between stem cells and hair shafts, and the mechanisms of action of stem cells in scalp aging, including alterations in signaling pathways, chromatin remodeling, and epigenetic regulation, etc. Furthermore, stem cell-based therapeutic strategies are summarized, such as the use of stem cells or their secreting exosomes, modulation of the stem cell microenvironment, and pharmacological interventions.

Key words: Hair follicle, Aging, Alopecia, Scalp, Hair regeneration, Epigenetics, Apoptosis, Exosomes

Ding Weiyun, Lin Jinran, Liu Qingmei, Zhang Yue, Yang Kai, Ni Chunya, Wu Wenyu, . Role of stem cells in scalp aging and related therapeutic strategies[J]. Chinese Journal of Dermatology, 2025, 58(7): 671-675.doi:10.35541/cjd.20240619

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Role of stem cells in scalp aging and related therapeutic strategies

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