脑源性神经营养因子与皮肤病

doi:10.35541/cjd.20210746

Abstract

Abstract: 【Abstract】 Brain-derived neurotrophic factor （BDNF）, a protein involved in the survival, growth and maintenance of neurons, plays an important role in pathophysiological processes in various neuropsychiatric diseases. In recent years, attention has been widely paid to the roles of BDNF in regulating immunity and participating in inflammatory reactions in non-nervous systems, and more and more studies have shown that BDNF plays an important role in various skin diseases, such as atopic dermatitis, connective tissue diseases and skin tumors. This review summarizes research advances in the role of BDNF in relevant skin diseases.

Key words: Dermatitis, atopic, Skin neoplasmas, Neuralgia, Connective tissue diseases, Brain-derived neurotrophic factor

CLC Number:

R751.05

Li Anqi, Sun Qiuning. Brain-derived neurotrophic factor and skin diseases[J]. Chinese Journal of Dermatology, 2025, 58(2): 190-193.doi:10.35541/cjd.20210746

References ［34］

［1］	Fernández⁃Rodríguez R, Álvarez⁃Bueno C, Martínez⁃Ortega IA, et al. Immediate effect of high⁃intensity exercise on brain⁃derived neurotrophic factor in healthy young adults: a systematic review and meta⁃analysis［J］. J Sport Health Sci, 2021,doi: 10.1016/j.jshs.2021.08.004.
［2］	Ribeiro FF, Xapelli S. Intervention of brain⁃derived neurotrophic factor and other neurotrophins in adult neurogenesis［J］. Adv Exp Med Biol, 2021,1331:95⁃115. doi: 10.1007/978⁃3⁃030⁃74046⁃7_8.
［3］	Nieto RR, Carrasco A, Corral S, et al. BDNF as a biomarker of cognition in schizophrenia/psychosis: an updated review［J］. Front Psychiatry, 2021,12:662407. doi: 10.3389/fpsyt.2021. 662407.
［4］	Barrios J, Ai X. Neurotrophins in asthma［J］. Curr Allergy Asthma Rep, 2018,18（2）:10. doi: 10.1007/s11882⁃018⁃0765⁃y.
［5］	Meng L, Liu B, Ji R, et al. Targeting the BDNF/TrkB pathway for the treatment of tumors［J］. Oncol Lett, 2019,17（2）:2031⁃2039. doi: 10.3892/ol.2018.9854.
［6］	Serafim Junior V, Fernandes G, Oliveira⁃Cucolo JG, et al. Role of tropomyosin⁃related kinase B receptor and brain⁃derived neurotrophic factor in cancer［J］. Cytokine, 2020,136:155270. doi: 10.1016/j.cyto.2020.155270.
［7］	Guzel T, Mech K, Iwanowska M, et al. Brain derived neurotrophic factor declines after complete curative resection in gastrointestinal cancer［J］. PeerJ, 2021,9:e11718. doi: 10.7717/peerj.11718.
［8］	Cao T, Matyas JJ, Renn CL, et al. Function and mechanisms of truncated BDNF receptor TrkB.T1 in neuropathic pain［J］. Cells, 2020,9（5）:1194. doi: 10.3390/cells9051194.
［9］	Fölster⁃Holst R, Papakonstantinou E, Rüdrich U, et al. Childhood atopic dermatitis⁃Brain⁃derived neurotrophic factor correlates with serum eosinophil cationic protein and disease severity［J］. Allergy, 2016,71（7）:1062⁃1065. doi: 10.1111/all. 12916.
［10］	Raap U, Goltz C, Deneka N, et al. Brain⁃derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects［J］. J Allergy Clin Immunol, 2005,115（6）:1268⁃1275. doi: 10.1016/j.jaci.2005.02.007.
［11］	Namura K, Hasegawa G, Egawa M, et al. Relationship of serum brain⁃derived neurotrophic factor level with other markers of disease severity in patients with atopic dermatitis［J］. Clin Immunol, 2007,122（2）:181⁃186. doi: 10.1016/j.clim.2006.10. 011.
［12］	Guseva D, Rüdrich U, Kotnik N, et al. Neuronal branching of sensory neurons is associated with BDNF⁃positive eosinophils in atopic dermatitis［J］. 2020,50（5）:577⁃584.
［13］	Tian B, Yang C, Wang J, et al. Peripheral blood brain⁃derived neurotrophic factor level and tyrosine kinase B expression on T lymphocytes in systemic lupus erythematosus: Implications for systemic involvement［J］. Cytokine, 2019,123:154764. doi: 10. 1016/j.cyto.2019.154764.
［14］	Zheng Q, Xu MJ, Cheng J, et al. Serum levels of brain⁃derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus［J］. Psychoneuroendocrinology, 2017,78:246⁃252. doi: 10.1016/j.psyneuen.2016.12.001.
［15］	田百玲, 刘旭东, 赵珊, 等. 皮肌炎患者外周血BDNF水平及受体TrkB在T淋巴细胞表达的研究［J］. 解剖科学进展, 2020,26（2）:166⁃169,173. doi: 10.16695/j.cnki.1006⁃2947.2020.02. 012.
［16］	Lise MC, Sparsa A, Marie I, et al. Serum neurotrophin profile in systemic sclerosis［J］. PLoS One, 2010,5（11）:e13918. doi: 10.1371/journal.pone.0013918.
［17］	Li YJ, Yang CS, Lei L, et al. Serum nerve grow factor and brain⁃derived neurotrophic factor profiles in Sjögren′s syndrome concomitant with interstitial lung disease［J］. Clin Rheumatol, 2014,33（8）:1161⁃1164. doi: 10.1007/s10067⁃014⁃2588⁃0.
［18］	Hang PZ, Ge FQ, Li PF, et al. The regulatory role of the BDNF/TrkB pathway in organ and tissue fibrosis［J］. Histol Histopathol, 2021,36（11）:1133⁃1143. doi: 10.14670/HH⁃18⁃368.
［19］	Qian Y, Takeuchi S, Chen SJ, et al. Nerve growth factor, brain⁃derived neurotrophic factor and their high⁃affinity receptors are overexpressed in extramammary Paget′s disease［J］. J Cutan Pathol, 2010,37（11）:1150⁃1154. doi: 10.1111/j.1600⁃0560.2010. 01563.x.
［20］	Suga H, Sugaya M, Miyagaki T, et al. Association of nerve growth factor, chemokine （C⁃C motif） ligands and immunoglobulin E with pruritus in cutaneous T⁃cell lymphoma［J］. Acta Derm Venereol, 2013,93（2）:144⁃149. doi: 10.2340/00015555⁃1428.
［21］	Antunes L, Cartell A, de Farias CB, et al. Tropomyosin⁃related kinase receptor and neurotrophin expression in cutaneous melanoma is associated with a poor prognosis and decreased survival［J］. Oncology, 2019,97（1）:26⁃37. doi: 10.1159/00049 9384.
［22］	Boshuizen J, Vredevoogd DW, Krijgsman O, et al. Reversal of pre⁃existing NGFR⁃driven tumor and immune therapy resistance［J］. Nat Commun, 2020,11（1）:3946. doi: 10.1038/s41467⁃020⁃17739⁃8.
［23］	Hama Y, Shiraki K, Yoshida Y, et al. Antibody to varicella⁃zoster virus immediate⁃early protein 62 augments allodynia in zoster via brain⁃derived neurotrophic factor［J］. J Virol, 2010,84（3）:1616⁃1624. doi: 10.1128/JVI.02061⁃09.
［24］	Wei X, Wang L, Hua J, et al. Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin⁃induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia［J］. J Neuroinflammation, 2021,18（1）:96. doi: 10.1186/s12974⁃021⁃02148⁃5.
［25］	李莉娟, 赵宪文, 禹香菊. 血清BDNF、NSE表达水平与带状疱疹后神经疼痛的相关性研究［J］. 皮肤性病诊疗学杂志, 2020,27（6）:414⁃417,422. doi: 10.3969/j.issn.1674⁃8468.2020.06.008.
［26］	Sjahrir M, Roesyanto⁃Mahadi ID, Effendy E. Correlation between serum brain⁃derived neurotrophic factor level and depression severity in psoriasis vulgaris patients［J］. Open Access Maced J Med Sci, 2019,7（4）:583⁃586. doi: 10.3889/oamjms.2019.142.
［27］	Aksoy H, Ergun T, Akkiprik M, et al. The impact of antipsoriatic treatment on serum pro⁃BDNF, BDNF levels, depression, anxiety scores, and quality of life［J］. Dermatol Ther, 2021,34（2）:e14872. doi: 10.1111/dth.14872.
［28］	JiaWen W, Hong S, ShengXiang X, et al. Depression⁃ and anxiety⁃like behaviour is related to BDNF/TrkB signalling in a mouse model of psoriasis［J］. Clin Exp Dermatol, 2018,43（3）:254⁃261. doi: 10.1111/ced.13378.
［29］	Rössing K, Novak N, Mommert S, et al. Brain⁃derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria［J］. Clin Exp Allergy, 2011,41（10）:1392⁃1399. doi: 10.1111/j.1365⁃2222.2011.03795.x.
［30］	Erpolat S, Celik HT, Bozkurt B. Brain⁃derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism［J］. Postepy Dermatol Alergol, 2017,34（4）:346⁃349. doi: 10.5114/ada.2017.69315.
［31］	Yanik ME, Erfan G, Albayrak Y, et al. Reduced serum brain⁃derived neurotrophic factor in patients with first onset vitiligo［J］. Neuropsychiatr Dis Treat, 2014,10:2361⁃2367. doi: 10.2147/ NDT.S74826.
［32］	He HY, Tian JL, Deng YQ, et al. Association of brain⁃derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris［J］. BMC Psychiatry, 2019,19（1）:193. doi: 10.1186/s12888⁃019⁃2182⁃8.
［33］	Peters EM, Hansen MG, Overall RW, et al. Control of human hair growth by neurotrophins: brain⁃derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta2 expression［J］. J Invest Dermatol, 2005,124（4）:675⁃685. doi: 10.1111/j.0022⁃202X.2005.23648.x.
［34］	Panchaprateep R, Korkij W, Asawanonda P. Brain⁃derived nerve factor and neurotrophins in androgenetic alopecia［J］. Br J Dermatol, 2011,165（5）:997⁃1002. doi: 10.1111/j.1365⁃2133. 2011.10514.x.

[1]	Zhang Yuanwen, Sun Congqian, Pan Wendong. Off-label clinical application of botulinum toxin in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(5): 471-475.
[2]	He Caifeng, Ci Chao, Lu Xiaohong, Yuan Tao, Yao Hui, Ji Yihuan, Wang Jun. Analysis of clinical and pathological features of 54 adult inpatients with erythema nodosum [J]. Chinese Journal of Dermatology, 2023, 56(7): 657-661.
[3]	Chinese Society of Dermatology, Chinese Association of Rehabilitation Dermatology, Combination of Traditional and Western Medicine Dermatology, The Dermatology Branch of Chinese Medical Education Association. Expert consensus on diagnosis and treatment of senile herpes zoster [J]. Chinese Journal of Dermatology, 2023, 56(2): 97-104.
[4]	Yang Yufeng, Li Yanhong, Wang Yuhui, Yan Runrun, Sun Wenjuan, Duan Yifei, Li Yan. Application status of electrical stimulation and repetitive transcranial magnetic stimulation in postherpetic neuralgia [J]. Chinese Journal of Dermatology, 2023, 56(1): 86-89.
[5]	Tian Jing, Liang Yuan, Shen Chunping, Zhao Mutong, Wang Yang, Wang Shan, Jiao Lei, Ma Lin. Analysis of short-term efficacy and safety of the first subcutaneous injection of dupilumab in the treatment of moderate-to-severe childhood atopic dermatitis [J]. Chinese Journal of Dermatology, 2022, 55(4): 299-303.
[6]	Consensus Workgroup on Herpes Zoster, China Dermatologist Association, National Clinical Research Center for Skin and Immune Diseases. Chinese consensus on the diagnosis and management of herpes zoster （2022） [J]. Chinese Journal of Dermatology, 2022, 55(12): 1033-1040.
[7]	Long Hai, Jiang Li, Qiu Yueqi, Yao Nan, Liu Licong, Xie Yuming, Xiong Feng, Tan Siqi, Kuang Qiqi, You Ruixuan, Chai Ke, Luo Xin, Long Haojun, Xin Yue, Guo Ziyu, Wang Jiaqi, Tan Yixin, Zhang Qing, Zhang Guiying, Li Yaping, Su Yuwen, Xiao Rong, Lu Qianjin, . Clinical analysis of 1 057 patients with critical illnesses in a dermatological ward [J]. Chinese Journal of Dermatology, 2021, 54(9): 790-797.
[8]	Committee on Autoimmune Diseases, China Dermatologist Association. Expert consensus on methotrexate in the treatment of immune-associated dermatoses [J]. Chinese Journal of Dermatology, 2021, 54(5): 382-390.
[9]	Committee on Autoimmune Diseases, China Dermatologist Association. Azathioprine in the treatment of immune?related skin diseases: an expert proposal [J]. Chinese Journal of Dermatology, 2021, 54(2): 116-121.
[10]	Xiang Ruiyu, Li Suo, Feng Suying. Application of pregabalin in dermatology [J]. Chinese Journal of Dermatology, 2020, 53(3): 233-235.
[11]	Jia Qiannan, Jin Hongzhong, Liu Yuehua, Ma Donglai, Qu Tao, Zeng Yueping, Wang Tao, Fang Kai, Li Nian. Analysis of clinical and pathological diagnoses of 29 987 skin biopsy samples in Peking Union Medical College Hospital [J]. Chinese Journal of Dermatology, 2020, 53(2): 117-120.
[12]	Li Hongxin, Zhao Yong, Hu Jin, Liu Xiaoyan. Clinical manifestations and cutaneous sequelae of neonatal lupus erythematosus: 13 case reports [J]. Chinese Journal of Dermatology, 2020, 53(10): 787-790.
[13]	Yang Xiaoxiao, Zheng Na′na, Zhong Liansheng, Pan Zhiqiang, Yu Zeyu. Changes in methylation status of the whole genome and GCH1 gene in patients with herpes zoster neuralgia [J]. Chinese Journal of Dermatology, 2019, 52(6): 420-424.
[14]	. Clinical analysis of 53 cases of disseminated herpes zoster [J]. Chinese Journal of Dermatology, 2016, 49(11): 806-809.
[15]	. Clinical efficacy of gabapentin plus glucocorticoids in the treatment of herpes zoster neuralgia [J]. Chinese Journal of Dermatology, 2012, 45(2): 145-146.

Brain-derived neurotrophic factor and skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［34］

Related Articles 15

Metrics

Comments

Recommended 10