Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (6): 552-558.doi: 10.35541/cjd.20230102

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Progress in the treatment of chronic spontaneous urticaria: insights from the changes in the understanding of its pathogenesis

Liang Yunsheng1,2, Li Zhanhong1,2, Wu Yibei1   

  1. 1Dermatology Hospital of Southern Medical University, Guangzhou 510091, China; 2Guangdong Clinical College of Dermatology, Anhui Medical University, Guangzhou 510091, China
  • Received:2023-02-24 Revised:2023-04-02 Online:2023-06-15 Published:2023-06-05
  • Contact: Liang Yunsheng
  • Supported by:
    National Natural Science Foundation of China (81972941); Guangdong Provincial Natural Science Foundation (2019A1515011561)

Abstract: 【Abstract】 Mast cells, autoantibodies, inflammatory cells, coagulation cascade, complement system and nervous system are all involved in the complex pathogenesis of chronic spontaneous urticaria (CSU), while mast cells play a pivotal role in it. With deeper understanding of the pathogenesis of CSU, cutting-edge therapeutic methods are gradually being used in clinical practice. Nowadays, pharmacotherapyeutic studies are more focused on accurately modulating the pathological state of mast cells. This review summarizes recent advances in the pathogenesis of and medicines for CSU.

Key words: Urticaria, Mast cells, Immunoglobulin E, Diagnosis, Treatment, Chronic spontaneous urticaria, Pathogenesis