Abstract: Yan Yi *, Liu Ruizhen, Xu Degang. *Department of Dermatology, Ganzhou Hospital of Dermatology, Ganzhou 341000, Jiangxi, China Corresponding author: Yan Yi, Email: yanyibest@tom.com 【Abstract】 Objective To evaluate the efficacy and safety of desloratadine citrate disodium versus epinastine for the treatment of chronic urticaria （CU）. Methods A randomized, double-blind, double-dummy controlled clinical trial was conducted. Patients with CU were divided into test group and control group to be treated by oral desloratadine citrate disodium （8.8 mg/d） and epinastine （10 mg/d） respectively once a day for 28 days. All the patients were followed up after starting treatment. Therapeutic effect was evaluated, and adverse reactions were observed. Results One hundred and fifty-seven patients were enrolled in this study, and 142 patients were valid for evaluation of efficacy and safety at the end of study. After treatment for 28 days, there was no significant difference between the test group and control group in response rate （81.16 % vs. 78.08 %, P > 0.05） or incidence rate of adverse reactions （13.89 % vs. 12.16 %, P > 0.05）. Conclusion Desloratadine citrate disodium is effective and safe for the treatment of CU.

Key words: Urticaria, Randomized controlled trials, Desloratadine citrate disodium, Epinastine