慢性自发性荨麻疹患者自体血清皮肤试验的免疫学机制及与临床特征和预后的关系

doi:10.35541/cjd.20210377

Abstract

Abstract: 【Abstract】 Autologous serum skin test （ASST） is commonly used as a screening test to assess immune subtypes of chronic spontaneous urticaria （CSU） in clinical practice, but its immunological mechanisms and associations with clinical features and prognosis of CSU are not yet clear. Studies have shown that positive ASST is associated with increased immunoglobulin G autoantibodies, decreased eosinophil and basophil counts, increased CD63 expression on basophils, and changes in circulating inflammatory cytokine levels in CSU patients, but not associated with age, disease duration, and personal or family history of CSU patients, and may be a predictor of severity of chronic urticaria. ASST-positive patients may respond poorly to second-generation H1 antihistamines, slowly to omalizumab, but respond well to cyclosporine and autologous whole blood/serum injections. This review summarizes the immunological and clinical characteristics of ASST-positive patients, and discusses the predictive value of positive ASST for the efficacy of different treatment regimens.

Key words: Urticaria, Chronic spontaneous urticaria, Autologous serum skin test, Immunoglobulin G, Omalizumab

Yu Miao, Song Xiaoting, Liu Bo, Liao Shuanglu, Luan Tingting, Zhao Zuotao. Autologous serum skin test: immunological mechanisms and its associations with clinical features and prognosis of chronic spontaneous urticaria[J]. Chinese Journal of Dermatology, 2023, 56(2): 184-187.doi:10.35541/cjd.20210377

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Autologous serum skin test: immunological mechanisms and its associations with clinical features and prognosis of chronic spontaneous urticaria

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