Abstract: Dai Weiwei *, Gao Lijuan, Liu Nan, Nie Zhenhua. *Tianjin Medical University, Tianjin 300070, China Corresponding author: Nie Zhenhua, Email: niezhenhua@163.com 【Abstract】 Objective To analyze causative factors for and therapeutic effect of total glucosides of paeony （TGP） on palmoplantar pustulosis（PPP）. Methods Ninety patients with PPP were recruited in this study. A questionnaire survey was carried out to collect clinical data from these patients, and a patch test to identify contact allergens for these patients. All the patients were randomly divided into two groups: observation group treated with TGP capsule 0.6 g thrice a day, and control group treated with tripterygium glycosides tablets 20 mg thrice a day. Both groups topically applied mometasone furoate cream once a day. The efficacy and side effects were evaluated 4 and 8 weeks after initiation of treatment. Results Of the 90 patients, the ratio of male to female was 1 ∶ 1.64, smokers amounted to 42.22％, and 23 （26.67%） reported a history of infection before the onset of PPP. As the patch test showed, potassium dichromate and nickel sulfate were the most common contact allergens in these patients. The response rate was significantly higher in the observation group than in the control group after 4 weeks of treatment （64.44％ vs. 40.00％, χ2 = 5.388, P ＜ 0.05）, but similar between the two groups after 8 weeks of treatment （88.89％ vs. 80.00％, χ2 = 1.353, P ＞ 0.05）. No significant difference was observed in the occurrence of adverse reactions between the two groups （17.78％ vs. 11.11％, χ2 = 0.809, P ＞ 0.05）. Conclusions Smoking may play a certain role in the development of PPP, and infection seems to be a primary inducing factor. TGP combined with mometasone furoate cream is effective for the treatment of PPP.

Key words: Palmoplantar pustulosis, Total glucosides of paeony, Questionnaires, Treatment outcome