Abstract: Zhang Ping, Li Lin, Li Kai, Cheng Yang, Jiang Kun, Wang Xiangdong, Chen Liuqing, Wang Weizhen. Department of Dermatology, Wuhan First Hospital, Wuhan 430022, China Corresponding author: Wang Weizhen, Email: weizhenwang2007@aliyun.com 【Abstract】 Objective To investigate the expressions of angiostatin and endostatin in different vascular proliferative skin diseases. Methods This study included 43 paraffin-embedded and 19 fresh skin tissue specimens from the lesions of patients with vascular proliferative skin diseases （such as capillary hemangioma, cavernous hemangioma, hemangioma racemosum, and pyogenic granuloma） as well as 6 fresh skin tissue specimens from the foreskin of infants. Immunohistochemistry and real-time qPCR were used to determine the expression pattern and levels of angiostatin and endostatin in these specimens. Results Both angiostatin and endostatin were expressed to a certain extent in the membrane and cytoplasm of vascular endothelial cells in these specimens of vascular proliferative skin diseases. The expression rates of angiostatin and endostatin in capillary hemangioma tissue specimens were 15.77% ± 5.92% and 19.35% ± 7.81% respectively, with their relative expression levels being 2.4 and 2.7 times those in the normal control skin specimens. No significant differences were observed in the expression level of angiostatin or endostatin between the normal control skin and lesions of the other vascular proliferative skin diseases （all P > 0.05）. Conclusions Angiostatin and endostatin are highly expressed in capillary hemangioma tissue, suggesting that they play biological roles in the pathogenesis of hemangioma via specifically acting against actively proliferating vascular endothelial cells.

Key words: Angiostatins, Endostatins, Hemangioma, capillary, Hemangioma, cavernous, Granuloma, pyogenic