Abstract: Shi Wei *, Zhang Jingwei, Xie Hongfu, Chen Xiang, Chen Mingliang. *Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China 【Abstract】 Two patients who developed typical skin eruptions 24 hours after consumption of shiitake mushrooms are reported. Case 1: a 56-year-old woman suddenly developed widespread itching eruptions one day after intake of shiitake mushrooms. On examination, there were erythematous and edematous linear streaks （flagellate erythema） over the neck, trunk and limbs. Case 2: a 60-year-old man presented with edematous flagellate erythema over the trunk and limbs for four days. He reported intake of shiitake mushroom several days prior to the presentation. Pathological examination revealed focal parakeratosis, intracellular and intercellular edema in the prickle cell layer, severe edema of papillary dermis, evident widening of interfibrous spaces, dilation and congestion of capillaries in the superficial dermis with a mixed perivascular infiltrate of massive lymphocytes and sparse neutrophils. Both patients were diagnosed with shiitake dermatitis, and treated with prednisone and antihistamines. The lesions subsided after 3 and 4 days of treatment in patient 1 and 2 respectively.

Key words: Dermatitis, Shiitake mushrooms, Case reports