Abstract: Wang Hui, Zhao Xueliang. Department of Dermatology, Weifang People′s Hospital, Weifang 261041, Shandong, China Corresponding author: Zhao Xueliang, Email: zhxl5801@163.com 【Abstract】 Objective To detect the changes in DNA loads of human papillomavirus （HPV） type 6/11 in lesions of patients with condyloma accuminatum （CA） before and after 5-aminolevulinic acid photodynamic therapy （ALA-PDT）. Methods After removal of warts by electrocautery, HPV6/11-positive patients with CA were divided into two groups: treatment group （32 cases） receiving two sessions of ALA-PDT with intervals of 7 － 10 days, and control group （29 cases） remaining untreated. Exfoliated cells were collected from the lesional sites of these patients before and 3 months after the first session of ALA-PDT, and fluorescence-based quantitative PCR was conducted to estimate the DNA loads of HPV 6/11 in these cells. Results Three months after the first session of ALA-PDT, 89.7% （26/29） of the patients in the treatment group and 68.4% （13/19） in the control group became HPV DNA negative, with significant differences between the treatment group and control group in the DNA loads of HPV （（1.70 ± 7.86） × 105 vs. （1.27 ± 2.21） × 106 copies/ml, P < 0.05）. Conclusion ALA-PDT can reduce HPV DNA loads in lesions of CA in patients.

Key words: Condylomata acuminata, Photochemotherapy, Human papillomavirus