Abstract: Objective To investigate the association of SPRR2E gene and psoriasis vulgaris by sequencing the DNA of Chinese Han psoriatic families.Methods DNA was extracted from the peripheral blood cells of thirty-two Chinese psoriatic families.The sequence of the SPRR2E encoding region was measured by ABI377 DNA Sequencer.The linkage disequilibrium was assessed by extended transmission disequilibrium test (ETDT) and GENEHUNTER software.Results An A/G polymorphism at nucleotide 156 of the SPRR2E encoding region was identified.There were three genotypes,including AA,GG and AG.Although the single nucleotide polymorphism (SNP) did not change the encoding of amino acid,the single nucleotide polymorphism locus was associated with psoriasis vulgaris by the ETDT analyzing.The A-allele was found to be transmitted more frequently than that of the G-allele.GENEHUNTER analysis was concordant with the Results of the ETDT.Conclusion A single nucleotide polymorphism (SNP) in SPRR2E gene encoding region is associated with psoriasis vulgaris in Han Chinese population.

Key words: Psoriasis, Genes, Polymorphism,single nucleotide