嗜酸性粒细胞在大疱性类天疱疮发病机制中的作用

doi:10.3760/cma.j.issn.0412-4030.2019.08.017

Abstract

Abstract: 【Abstract】 Bullous pemphigoid （BP） is the most common autoimmune subepidermal blistering skin disease, and a large number of eosinophils （EOS） obviously infiltrate the dermis of BP lesions. Additionally, EOS and their activated cytokines and chemokines are abundantly present in blisters and peripheral blood of BP patients. It is also proved that EOS can induce the dermal-epidermal separation. The level of interleukin （IL）-5 is markedly increased in the sera and blister fluids of BP patients, and IL-5 secreted by Th2 cells and EOS can regulate the differentiation, activation and survival of EOS. All the above evidence indicates that EOS are associated with the occurrence of BP. Researches on EOS and their cytokines will develop a new field of targeted therapy for BP.

Key words: Pemphigoid, bullous, Eosinophil, Pathogenesis, Dermal?epidermal separation

Shen Jia, Yuan Huijie, Pan Meng. Role of eosinophils in the pathogenesis of bullous pemphigoid[J].Chinese Journal of Dermatology, 2019, 52(8): 579-581.

References ［35］

［1］	della TR, Combescure C, Cortés B, et al. Clinical presentation and diagnostic delay in bullous pemphigoid: a prospective nationwide cohort［J］. Br J Dermatol, 2012,167（5）:1111⁃1117. doi: 10.1111/j.1365⁃2133.2012.11108.x.
［2］	Amber KT, Valdebran M, Kridin K, et al. The role of eosinophils in bullous pemphigoid: a developing model of eosinophil pathogenicity in mucocutaneous disease［J/OL］. Front Med （Lausanne）, 2018,5:201. ［2018⁃08⁃02］. https://www. frontiersin.org/articles/10.3389/fmed.2018.00201/full. doi: 10.3389/ fmed.2018.00201.
［3］	Messingham KN, Wang JW, Holahan HM, et al. Eosinophil localization to the basement membrane zone is autoantibody⁃ and complement⁃dependent in a humancryosection model of bullous pemphigoid［J］. Exp Dermatol, 2016,25（1）:50⁃55. doi: 10.1111/exd.12883.
［4］	Tedeschi A, Marzano AV, Lorini M, et al. Eosinophil cationic protein levels parallel coagulation activation in the blister fluid of patients with bullous pemphigoid［J］. J Eur Acad Dermatol Venereol, 2015,29（4）:813⁃817. doi: 10.1111/jdv.12464.
［5］	van Beek N, Schulze FS, Zillikens D, et al. IgE⁃mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases［J］. Expert Rev Clin Immunol, 2016,12（3）:267⁃277. doi: 10.1586/1744666X.2016.1123092.
［6］	Diny NL, Rose NR, Čiháková D. Eosinophils in autoimmune diseases［J/OL］. Front Immunol, 2017,8:484. ［2017⁃06⁃22］. https://www.frontiersin.org/articles/10.3389/fimmu.2017.00484/full. doi: 10.3389/fimmu. 2017.00484.
［7］	Morshed M, Yousefi S, Stöckle C, et al. Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps［J］. Allergy, 2012,67（9）:1127⁃1137. doi: 10.1111/j.1398⁃9995.2012.02868.x.
［8］	Yousefi S, Gold JA, Andina N, et al. Catapult⁃like release of mitochondrial DNA by eosinophils contributes to antibacterial defense［J］. Nat Med, 2008,14（9）:949⁃953. doi: 10.1038/nm. 1855.
［9］	Choi Y, Le PD, Lee DH, et al. Biological function of eosinophil extracellular traps in patients with severe eosinophilic asthma［J］. Exp Mol Med, 2018,50（8）:104. doi: 10.1038/s12276⁃018⁃0136⁃8.
［10］	Lin L, Hwang BJ, Culton DA, et al. Eosinophils mediate tissue injury in the autoimmune skin disease bullous pemphigoid［J］. J Invest Dermatol, 2018,138（5）:1032⁃1043. doi: 10.1016/j.jid. 2017.11.031.
［11］	Januskevicius A, Gosens R, Sakalauskas R, et al. Suppression of eosinophil integrins prevents remodeling of airway smooth muscle in asthma［J/OL］. Front Physiol, 2016,7:680. ［2017⁃12⁃28］. https://www.frontiersin.org/articles/10.3389. doi: 10.3389/fphys.2016.00680.
［12］	Lampinen M, Carlson M, Håkansson LD, et al. Cytokine⁃regulated accumulation of eosinophils in inflammatory disease［J］. Allergy, 2004,59（8）:793⁃805. doi: 10.1111/j.1398⁃9995. 2004.00469.x.
［13］	Foley SC, Préfontaine D, Hamid Q. Images in allergy and immunology: role of eosinophils in airway remodeling［J］. J Allergy Clin Immunol, 2007,119（6）:1563⁃1566. doi: 10.1016/j.jaci.2007. 03.040.
［14］	Lamkhioued B, Gounni AS, Aldebert D, et al. Synthesis of type 1 （IFN gamma） and type 2 （IL⁃4, IL⁃5, and IL⁃10） cytokines by human eosinophils［J］. Ann N Y Acad Sci, 1996,796:203⁃208.
［15］	Ohno I, Nitta Y, Yamauchi K, et al. Transforming growth factor beta 1 （TGF beta 1） gene by eosinophils in asthmatic airway inflammation［J］. Am J Respir Cell Mol Biol, 1996,15（3）:404⁃409. doi: 10.1165/ajrcmb.15.3.8810646.
［16］	Wang YH, Liu YJ. Thymic stromal lymphopoietin, OX40⁃ligand, and interleukin⁃25 in allergic responses［J］. Clin Exp Allergy, 2009,39（6）:798⁃806. doi: 10.1111/j.1365⁃2222.2009.03241.x.
［17］	Peters MS, Rodriguez M, Gleich GJ. Localization of human eosinophil granule major basic protein, eosinophil cationic protein, and eosinophil⁃derived neurotoxin by immunoelectron microscopy［J］. Lab Invest, 1986,54（6）:656⁃662.
［18］	Gleich GJ, Frigas E, Loegering DA, et al. Cytotoxic properties of the eosinophil major basic protein［J］. J Immunol, 1979,123（6）:2925⁃2927.
［19］	Young JD, Peterson CG, Venge P, et al. Mechanism of membrane damage mediated by human eosinophil cationic protein［J］. Nature, 1986,321（6070）:613⁃616. doi: 10.1038/321613a0.
［20］	Ramirez GA, Yacoub MR, Ripa M, et al. Eosinophils from physiology to disease: a comprehensive review［J］. Biomed Res Int, 2018,2018:9095275. doi: 10.1155/2018/9095275.
［21］	Watanabe H, Sueki H, Kitami A, et al. Flame figures associated with bullous pemphigoid［J］. J Dermatol, 1998,25（10）:632⁃636.
［22］	de Graauw E, Sitaru C, Horn M, et al. Evidence for a role of eosinophils in blister formation in bullous pemphigoid［J］. Allergy, 2017,72（7）:1105⁃1113. doi: 10.1111/all.13131.
［23］	Kridin K. Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation［J］. Br J Dermatol, 2018,179（5）:1141⁃1147. doi: 10.1111/bjd.16679.
［24］	Moriuchi R, Nishie W, Ujiie H, et al. In vivo analysis of IgE autoantibodies in bullous pemphigoid: a study of 100 cases［J］. J Dermatol Sci, 2015,78（1）:21⁃25. doi: 10.1016/j.jdermsci.2015. 01.013.
［25］	Kinet JP. The high⁃affinity IgE receptor （Fc epsilon RI）: from physiology to pathology［J］. Annu Rev Immunol, 1999,17:931⁃972. doi: 10.1146/annurev.immunol.17.1.931.
［26］	Wakugawa M, Nakamura K, Hino H, et al. Elevated levels of eotaxin and interleukin⁃5 in blister fluid of bullous pemphigoid: correlation with tissue eosinophilia［J］. Br J Dermatol, 2000,143（1）:112⁃116.
［27］	Engmann J, Rüdrich U, Behrens G, et al. Increased activity and apoptosis of eosinophils in blister fluids, skin and peripheral blood of patients with bullous pemphigoid［J］. Acta Derm Venereol, 2017,97（4）:464⁃471. doi: 10.2340/00015555⁃2581.
［28］	Ståhle⁃Bäckdahl M, Inoue M, Guidice GJ, et al. 92⁃kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180⁃kD bullous pemphigoid autoantigen［J］. J Clin Invest, 1994,93（5）:2022⁃2030. doi: 10.1172/JCI117196.
［29］	Bushkell LL, Jordon RE. Bullous pemphigoid: a cause of peripheral blood eosinophilia［J］. J Am Acad Dermatol, 1983,8（5）:648⁃651.
［30］	Nakashima H, Fujimoto M, Asashima N, et al. Serum chemokine profile in patients with bullous pemphigoid［J］. Br J Dermatol, 2007,156（3）:454⁃459. doi: 10.1111/j.1365⁃2133.2006.07601.x.
［31］	Lamberts A, Euverman HI, Terra JB, et al. Effectiveness and safety of rituximab in recalcitrant pemphigoid diseases［J/OL］. Front Immunol, 2018,9:248. ［2018⁃05⁃22］. https://www.frontiersin.org/articles/10.3389/fimmu.2018.00248/full. doi: 10. 3389/fimmu.2018.00248.
［32］	Menzinger S, Kaya G, Schmidt E, et al. Biological and clinical response to omalizumab in a patient with bullous pemphigoid［J］. Acta Derm Venereol, 2018,98（2）:284⁃286. doi: 10.2340/000 15555⁃2845.
［33］	Roufosse F. Targeting the interleukin⁃5 pathway for treatment of eosinophilic conditions other than asthma［J/OL］. Front Med （Lausanne）, 2018,5:49. ［2018⁃06⁃03］. https://www.frontiersin.org/articles/10.3389/fmed.2018.00049/full. doi: 10.3389/fmed. 2018.00049.
［34］	Radonjic⁃Hoesli S, Valent P, Klion AD, et al. Novel targeted therapies for eosinophil⁃associated diseases and allergy［J］. Annu Rev Pharmacol Toxicol, 2015,55:633⁃656. doi: 10.1146/annurev⁃pharmtox⁃010814⁃124407.
［35］	Gounni AS, Wellemans V, Agouli M, et al. Increased of Th2⁃associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines［J］. Clin Immunol, 2006,120（2）:220⁃231. doi: 10. 1016/j.clim.2006.03.014.

[1]	. γ-Secretase mutations in acne inversa [J]. Chinese Journal of Dermatology, 2019, 52(9): 656-659.
[2]	Zhao Qingping, Fang Jie, Wang Baoren, Lin Weiqing. Surgical resection and skin graft repair for a case of angiolymphoid hyperplasia with eosinophilia of the posterior ear [J]. Chinese Journal of Dermatology, 2019, 52(8): 568-569.
[3]	Chen Yiwen, Su Ting, Su Zhonglan. Association between psoriasis and STAT3 [J]. Chinese Journal of Dermatology, 2019, 52(7): 502-505.
[4]	Rao Shijia, Li Bijuan, Li Ji, Xie Hongfu, Chen Mingliang, Zhao Shuang, Wang Yaling, Shi Wei, Lu Qianjin. Efficacy of combined lymphoplasma exchange for the treatment of severe refractory immune-related skin diseases: a clinical observation [J]. Chinese Journal of Dermatology, 2019, 52(1): 16-19.
[5]	Zhang Nan, Wang Lian, Liu Lian, Du Dan, Jiang Xian. A case of angiolymphoid hyperplasia with eosinophilia treated with Nd:YAG laser [J]. Chinese Journal of Dermatology, 2019, 0(0): 20180666-20180666.
[6]	. Analysis of diagnosis and treatment of a case of drug-induced hypersensitivity syndrome by lithium carbonate [J]. Chinese Journal of Dermatology, 2018, 51(9): 680-681.
[7]	Li Sizhe, Yan Tianmeng, Li Li, Jin Hongzhong, Zuo Yagang. There is no correlation between the serum level of interleukin-21 and bullous pemphigoid [J]. Chinese Journal of Dermatology, 2018, 51(8): 595-596.
[8]	Qing-wei Geng Wang-Min. Clinicopathological analysis of 22 cases of cutaneous epithelioid hemangioma [J]. Chinese Journal of Dermatology, 2018, 51(6): 459-462.
[9]	Liu Jiawei, Li Sizhe, Li Feng, Liu Wei, Fang Kai, Ma Donglai. A case of eosinophilic annular erythema [J]. Chinese Journal of Dermatology, 2017, 50(12): 927-928.
[10]	. A case of generalized bullous morphea [J]. Chinese Journal of Dermatology, 2016, 49(8): 601-602.
[11]	. A case of preadolescent acne inversa [J]. Chinese Journal of Dermatology, 2016, 49(6): 434-434.
[12]	Ying YANG. Acne and diet [J]. Chinese Journal of Dermatology, 2015, 48(6): 440-442.
[13]	Ling-Yan Wang. Advances in the pathogenesis of cutaneous malignancies in 2014 [J]. Chinese Journal of Dermatology, 2015, 48(11): 822-825.
[14]	zhenhua wang. Expressions of interleukin-22 in sera and peripheral blood mononuclear cells of patients with pityriasis rosea [J]. Chinese Journal of Dermatology, 2014, 47(10): 746-747.
[15]	. Clinical efficacy of thalidomide, mometasone furoate cream under occlusion and ultraviolet irradiation for the treatment of prurigo nodularis [J]. Chinese Journal of Dermatology, 2012, 45(11): 820-822.

Role of eosinophils in the pathogenesis of bullous pemphigoid

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References ［35］

Related Articles 15

Metrics

Comments

Recommended 10